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Abstract

Imidacloprid (Figure 1) is the first active ingredient of the chemical class of nicotinoid insecticides to reach the market. Toxicological information on this class of substances is nearly nonexistent in open literature. Only limited toxicological information on the structurally related compound nitroguanidine is available, and it indicates no critical toxicological properties (GRA & 11986–1990).

Keywords

Good Laboratory Practice Nerve Termin Body Weight Gain Reduction Toxicological Information Maternal Toxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. GRA & I (1986-1990) Government reports announcements & index (U.S.), Issues 5,11,12,15,16,17,19,23Google Scholar
  2. MAFF, Japan (1984) Ministry of Agriculture, Forestry and Fisheries. On good laboratory practice standards for toxicological studies on agriculture chemicals. 59 NohSan No. 3850, August 10Google Scholar
  3. MAFF, Japan (1985) Ministry of Agriculture, Forestry and Fisheries. Guidance on toxicology study data for application of agriculture chemical registration. 59 NohSan No. 4200, January 28Google Scholar
  4. Methfessel C (1992) Action of Imidacloprid on the nicotinergic acetylcholine receptors in rat muscle. Pflanz Nachr Bayer 45:369–380Google Scholar
  5. OECD (1981) Organization for Economic Co-operation and Development. Guidelines for testing of chemicals. ParisGoogle Scholar
  6. OECD (1981) Principles of good laboratory practice. C(81)30 (Final) Annex 2, ParisGoogle Scholar
  7. Schroeder ME, Flattum RF (1984) The mode of action of neurotoxic properties of the nitromethylene heterocyclic insecticides. Pestic Biochem Physiol 22:148–160CrossRefGoogle Scholar
  8. US-EPA-FIFRA (1991) Pesticide assessment guidelines, subdivision F, hazard evaluation: human and domestic animalsGoogle Scholar
  9. US-EPA-FIFRA (1991) Good laboratory practice standards, 40 CFR part 160Google Scholar
  10. Yamamoto I, Yabuta G, Tomizawa M, Saito T, Miyamota T, Kagabu S (1984) Molecular mechanisms for selective toxicity of nicotinoids and neonicotinoids. J Pestic Sci 20:33–40CrossRefGoogle Scholar

Copyright information

© Springer Japan 1999

Authors and Affiliations

  • J. Thyssen
    • 1
  • L. Machemer
    • 2
  1. 1.Agriculture DivisionToxicology, Bayer CorporationStillwell, KansasUSA
  2. 2.Bayer AG, BG HealthInstitute of ToxicologyWuppertalGermany

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