Vascular Activities of Hemoglobin-Based Oxygen Carriers: Relationship Between Vasoconstrictive Activity and Endothelial Permeability
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Acellular hemoglobin (Hb)-based oxygen carriers have been studied for the substitution of red blood cell transfusion. However, they have been shown to induce several undesired reactions such as hypertension, gastrointestinal symptoms and platelet activation. Hb-induced scavenging of nitric oxides might be responsible for the backgrounds of these reactions. Based on several in vitro experiments, we propose a hypothesis that acellular Hb derivatives having smaller molecular masses have increased endothelial permeabilities and therefore induce more potent vasoconstriction as a result of abluminal nitric oxide scavenging.
Key WordsBlood substitutes Endothelial permeability Hemoglobin Nitric oxide Vasoconstriction
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