Abstract
Peritoneal carcinomatosis is the most common mode of post-operative recurrence in gastric cancer patients [1], Prophylactic intraperitoneal administration of anticancer drugs in aqueous solution is not always efficacious. The small water-soluble molecules in commonly used anticancer drugs are absorbed rapidly from the peritoneal cavity into the circulation [2] and cannot maintain the concentration at an effective level for a long time. In contrast, corpuscular particles are gradually absorbed and are retained in the cavity [3]. We have developed a new dosage formulation to administer an anticancer drug in which mitomycin C is adsorbed onto activated carbon particles (MMC-CH). We present here basic experiments and a clinical study on the prophylactic effects of MMC-CH against peritoneal recurrence of gastric cancer.
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© 1999 Springer Japan
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Hagiwara, A., Takahashi, T., Yamagishi, H. (1999). Activated Carbon Particles Adsorbing Mitomycin C Used Against Peritoneal Carcinomatosis in Gastric Cancer. In: Nakajima, T., Yamaguchi, T. (eds) Multimodality Therapy for Gastric Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67927-1_6
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DOI: https://doi.org/10.1007/978-4-431-67927-1_6
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68009-3
Online ISBN: 978-4-431-67927-1
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