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Activated Carbon Particles Adsorbing Mitomycin C Used Against Peritoneal Carcinomatosis in Gastric Cancer

  • Akeo Hagiwara
  • Toshio Takahashi
  • Hisakazu Yamagishi

Abstract

Peritoneal carcinomatosis is the most common mode of post-operative recurrence in gastric cancer patients [1], Prophylactic intraperitoneal administration of anticancer drugs in aqueous solution is not always efficacious. The small water-soluble molecules in commonly used anticancer drugs are absorbed rapidly from the peritoneal cavity into the circulation [2] and cannot maintain the concentration at an effective level for a long time. In contrast, corpuscular particles are gradually absorbed and are retained in the cavity [3]. We have developed a new dosage formulation to administer an anticancer drug in which mitomycin C is adsorbed onto activated carbon particles (MMC-CH). We present here basic experiments and a clinical study on the prophylactic effects of MMC-CH against peritoneal recurrence of gastric cancer.

Keywords

Gastric Cancer Activate Carbon Gastric Cancer Patient Peritoneal Carcinomatosis Peritoneal Recurrence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 1999

Authors and Affiliations

  • Akeo Hagiwara
    • 1
  • Toshio Takahashi
    • 1
  • Hisakazu Yamagishi
    • 1
  1. 1.First Department of SurgeryKyoto Prefectural University of MedicineKyotoJapan

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