Meta-Analysis of Adjuvant Chemotherapy Trials for Gastric Cancer at the Cancer Institute Hospital, Tokyo

  • Toshifusa Nakajima
  • Keiichiro Ohta
  • Shigekazu Ohyama
  • Nobuyuki Hamajima


Despite a long history of clinical trials for adjuvant chemotherapy for gastric cancer, standard adjuvant chemotherapy is not yet established. Most Western trials produced no survival benefit with postoperative adjuvant chemotherapy [1], but there are a few encouraging reports from Japan [2, 3, 4]. The Japanese studies reported a marginal survival benefit in certain subsets, but it did not, as a whole, reach statistical significance. Failure to prove statistical significance is partly attributed to small sample size. Repeating a trial with encouraging but old regimens to confirm marginal efficacy is not a realistic solution: It is time-consuming and not attractive to clinical investigators. Meta-analysis may be, in such cases, an alternate approach to evaluating the clinical significance of previous trials of adjuvant chemotherapy.


Gastric Cancer Adjuvant Chemotherapy Gastric Cancer Patient Cytosine Arabinoside Resectable Gastric Cancer 
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Copyright information

© Springer Japan 1999

Authors and Affiliations

  • Toshifusa Nakajima
    • 1
  • Keiichiro Ohta
    • 1
  • Shigekazu Ohyama
    • 1
  • Nobuyuki Hamajima
    • 2
  1. 1.Department of SurgeryCancer Institute HospitalTokyoJapan
  2. 2.Division of EpidemiologyAichi Cancer Center Research InstituteJapan

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