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Multimodality Therapy for Gastric Cancer pp 27–31Cite as

Meta-Analysis of Adjuvant Chemotherapy Trials for Gastric Cancer at the Cancer Institute Hospital, Tokyo

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Abstract

Despite a long history of clinical trials for adjuvant chemotherapy for gastric cancer, standard adjuvant chemotherapy is not yet established. Most Western trials produced no survival benefit with postoperative adjuvant chemotherapy [1], but there are a few encouraging reports from Japan [2–4]. The Japanese studies reported a marginal survival benefit in certain subsets, but it did not, as a whole, reach statistical significance. Failure to prove statistical significance is partly attributed to small sample size. Repeating a trial with encouraging but old regimens to confirm marginal efficacy is not a realistic solution: It is time-consuming and not attractive to clinical investigators. Meta-analysis may be, in such cases, an alternate approach to evaluating the clinical significance of previous trials of adjuvant chemotherapy.

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Authors and Affiliations

  1. Department of Surgery, Cancer Institute Hospital, 1-37-1 Kamiikebukuro, Toshima-ku, Tokyo, 170-8455, Japan

    Toshifusa Nakajima, Keiichiro Ohta & Shigekazu Ohyama

  2. Division of Epidemiology, Aichi Cancer Center Research Institute, Japan

    Nobuyuki Hamajima

Authors
  1. Toshifusa Nakajima
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  2. Keiichiro Ohta
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  3. Shigekazu Ohyama
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  4. Nobuyuki Hamajima
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Editor information

Editors and Affiliations

  1. Cancer Institute Hospital, 1-37-1 Kamiikebukuro, Toshima-ku, Tokyo, 170-8455, Japan

    Toshifusa Nakajima M.D., Ph.D. (Vice Director) (Vice Director)

  2. The First Department of Surgery, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 602-0841, Japan

    Toshiharu Yamaguchi M.D., Ph.D. (Associate Professor) (Associate Professor)

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© 1999 Springer Japan

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Nakajima, T., Ohta, K., Ohyama, S., Hamajima, N. (1999). Meta-Analysis of Adjuvant Chemotherapy Trials for Gastric Cancer at the Cancer Institute Hospital, Tokyo. In: Nakajima, T., Yamaguchi, T. (eds) Multimodality Therapy for Gastric Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67927-1_4

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  • DOI: https://doi.org/10.1007/978-4-431-67927-1_4

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68009-3

  • Online ISBN: 978-4-431-67927-1

  • eBook Packages: Springer Book Archive

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