Advertisement

Randomized Controlled Trials on Adjuvant Therapy for Gastric Cancer: Japanese Experience

  • Takeshi Sano
  • Mitsuru Sasako
  • Hitoshi Katai
  • Keiichi Maruyama

Abstract

The treatment outcomes of gastric cancer in Japan have steadily improved over the past three decades [1], whereas those in Western countries are rather stable in a depressing status. The improvement in Japan seems to be largely attributable to the increase of early detection and consequent curative resection of the tumor. The impact of chemotherapy has been relatively small, and the results of noncurative resection or nonresectable cases remain poor.

Keywords

Gastric Cancer Adjuvant Chemotherapy Gastric Cancer Patient Japan Clinical Oncology Group Curative Gastrectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Sasako M, Sano T, Katai H, Maruyama K (1997) Radical surgery. In: Sugimura T, Sasako M (eds) Gastric cancer. Oxford University Press, Oxford, pp 223–248Google Scholar
  2. 2.
    Italian Gastrointestinal Tumour Study Group (1988) Adjuvant treatments following curative resection for gastric cancer. Br J Surg 75:1100–1104CrossRefGoogle Scholar
  3. 3.
    Hallissey MT, Dunn JA, Ward LC, Allum WH (1994) The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: five year follow up. Lancet 343:1309–1312PubMedCrossRefGoogle Scholar
  4. 4.
    Shimoyama M, Fukuda H, Saijo N, Yamaguchi N (1998) Japan Clinical Oncology Group (JCOG). Jpn J Clin Oncol 28:158–162PubMedCrossRefGoogle Scholar
  5. 5.
    Fujii S, Ikenaka K, Fukushima M, Shirasaka (1978) Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(-2-tetrahydrofuryl)-5-fluorouracil. Gann 69:763–772PubMedGoogle Scholar
  6. 6.
    Tsukagoshi S, Hashimoto Y, Fujii G, Kobayashi H, Nomoto K, Orita K (1984) Krestin (PSK). Cancer Treat Rev 11:131–55PubMedCrossRefGoogle Scholar
  7. 7.
    Uchida A, Micksche M (1983) Intrapleural administration OK-432 in cancer patients: activation of NK cells and reduction of suppressor cells. Int J Cancer 31:1–5PubMedCrossRefGoogle Scholar
  8. 8.
    Nakajima T, Ota K, Ishihara S, Oyama S, Nishi M, Hamashima N (1994) Meta-analysis of postoperative adjuvant chemotherapies for gastric cancer in Cancer Institute Hospital. Gan to Kagaku Ryoho 21:1800–1805PubMedGoogle Scholar
  9. 9.
    Azuma I, Taniyama T, Yamasaki M, Sugimura K, Yamamura Y (1976) Adjuvant and antitumor activities of Nocardia cell-wall skeletons. Gann 67:733–736PubMedGoogle Scholar
  10. 10.
    Kondo T, Ichihashi H, Nakazato H, et al (1989) Result of adjuvant immunochemotherapy on 8-year survival using KRESTIN and Futraful for gastric cancer patients who underwent radical gastrectomy: a randomized controlled trial by cooperative study group (in Japanese). Biotherapy 3:655–664Google Scholar
  11. 11.
    Hagiwara A, Takahashi T, Kojima O, Sawai K, Yamaguchi T, Yamane T, Taniguchi H, Kitamura K, Noguchi A, Seiki K, Sakakura C (1992) Prophylaxis with carbon-adsorbed mitomycin against peritoneal recurrence of gastric cancer. Lancet 339:629–631PubMedCrossRefGoogle Scholar
  12. 12.
    Rosen HR, Jatzko G, Repse S, Potrc S, Neudorfer H, Sandbichler P, Zacherl J, Rabl H, Holzberger P, Lisborg P, Czeijka M (1998) Adjuvant intraperitoneal chemotherapy with carbon-adsorbed mitomicin in patients with gastric cancer: results of a randomized multicenter trial of the Austrian Working Group for Surgical Oncology. J Clin Oncol 16:2733–2738PubMedGoogle Scholar
  13. 13.
    Hamazoe R, Maeta M, Kaibara N (1994) Intraperitoneal thermochemotherapy for prevention of peritoneal recurrence of gastric cancer. Cancer 73:2048–2052PubMedCrossRefGoogle Scholar
  14. 14.
    Medical Research Council (1948) Streptomycin treatment of pulmonary tuberculosis. BMJ 2:769–782CrossRefGoogle Scholar
  15. 15.
    Altman DG (1996) Better reporting of randomised controlled trials: the CONSORT statement. BMJ 313:570–571PubMedCrossRefGoogle Scholar
  16. 16.
    Begg C, Cho M, Eastwood S, Horton R, Moher D, Olkin I, Pitkin R, Rennie D, Schulz KF, Simel D, Stroup D (1996) Improving the quality of reporting of randomized controlled trials: the CONSORT statement. JAMA 276:637–639PubMedCrossRefGoogle Scholar
  17. 17.
    Fukuda H, Ohashi Y (1997) A guideline for reporting results of statistical analysis. Jpn J Clin Oncol 27(3):121–127PubMedCrossRefGoogle Scholar
  18. 18.
    Kunii Y, Kikuchi K, Tanabe T, Abe O, Kondo T, Taguchi T, Hattori T, Komi N, Nakazato H, Nakajima T, Miwa K, Inokuchi K (1989) Adjuvant chemotherapy for gastric cancer: The third study. First report: central randomization by telephone method and analysis of patient’s background factors. Gan to Kagaku Ryoho 16:349–355PubMedGoogle Scholar
  19. 19.
    Simon R, Wittes RE (1985) Methodologic guidelines for reports of clinical trials. Cancer Treat Rep 69:1–3PubMedGoogle Scholar
  20. 20.
    Moher D, Dulberg CS, Wells GA (1994) Statistical power, sample size, and their reporting in randomized controlled trials. JAMA 272:122–124PubMedCrossRefGoogle Scholar
  21. 21.
    Pocock SJ, Hughes MD, Lee RJ (1987) Statistical problems in the reporting of clinical trials: a survey of three medical journals. N Engl J Med 317:426–432PubMedCrossRefGoogle Scholar
  22. 22.
    Nakajima T (1990) Adjuvant chemotherapy for gastric cancer in Japan: present status and suggestions for rational clinical trials. Jpn J Clin 20 (1):30–42Google Scholar
  23. 23.
    Sasako M, Sano T, Katai H, Okajima K, Maruyama K (1994) Overview of clinical trials on adjuvant chemotherapy for curatively resected gastric cancer. Gan to Kagaku Ryoho 21:384–394PubMedGoogle Scholar
  24. 24.
    Nakajima T (1995) Review of adjuvant chemotherapy for gastric cancer. World J Surg 19:570–574PubMedCrossRefGoogle Scholar
  25. 25.
    Fukushima M (1996) Adjuvant therapy of gastric cancer: the Japanese experience. Semin Oncol 23:369–378PubMedGoogle Scholar
  26. 26.
    Kakizoe T (ed) (1997) Cancer statistics in Japan. Foundation for Promotion of Cancer Research, TokyoGoogle Scholar

Copyright information

© Springer Japan 1999

Authors and Affiliations

  • Takeshi Sano
    • 1
  • Mitsuru Sasako
    • 1
  • Hitoshi Katai
    • 1
  • Keiichi Maruyama
    • 1
  1. 1.Gastric Surgery DivisionNational Cancer Center HospitalTokyoJapan

Personalised recommendations