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Management of Liver Metastases

  • Yasuaki Arai

Abstract

Liver metastasis indicates a poor prognosis in patients with advanced or recurrent gastric cancer. Therefore, treatment for a primary lesion of gastric cancer, including gastrectomy and lymphadenectomy, has sometimes not been undertaken because of the presence of liver metastases. New approaches to treat patients with liver metastases, such as hepatic resection, second-generation combination systemic chemotherapy, and hepatic arterial infusion chemotherapy, have sometimes shown good control of liver metastases and have produced long survivals. These advances in the treatment of liver metastases have changed the therapeutic strategy for gastric cancer patients with liver metastases.

Keywords

Gastric Cancer Liver Metastasis Hepatic Artery Hepatic Resection Systemic Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Yamamura Y, Kito T, Hirai T, et al (1989) Evaluation of treatment for gastric cancer with liver metastasis. Jpn J Gastroenterol Surg 22:2503–2506CrossRefGoogle Scholar
  2. 2.
    Yamamura Y, Kodera Y, Shimizu Y, et al (1998) Management of gastric carcinoma at Aichi Cancer Center: an audit of 4839 cases treated during past 25 years and reports on the recent advances in detection and treatment of distant metastases. Jpn J Gastroenterol Surg 31:2136–2140CrossRefGoogle Scholar
  3. 3.
    Jacques Wils (1996) The treatment of advanced gastric cancer. Semin Oncol 23:397–406Google Scholar
  4. 4.
    Arai Y, Inaba Y, Takeuchi Y (1997) Interventional techniques for hepatic arterial infusion chemotherapy. In: Castaneda-Zuniga WR (ed) Interventional radiology, 3rd edn. Williams & Wilkins, Baltimore, pp 192–205Google Scholar
  5. 5.
    Arai Y, Endo T, Sone Y, et al (1992) Management of patients with unresectable liver metastases from colorectal and gastric cancer employing an implantable port system. Cancer Chemother Pharmacol 31(suppl I):S99–S102PubMedCrossRefGoogle Scholar
  6. 6.
    Arai Y, Sone Y, Tohyama N, et al (1992) Hepatic arterial infusion for unresectable liver metastases from gastric cancer. Proc ASCO 11:176Google Scholar
  7. 7.
    Ito K, Arai Y, Kumada T, et al (1994) Multi-institutional study of hepatic arterial infusion chemotherapy for liver metastases from gastric cancer using 5-FU, EPIR and MMC. Jpn J Cancer Chemother 30:1377Google Scholar
  8. 8.
    Horn DC, Stagg RJ, Friedman MA, et al (1989) A randomized trial of continuous intravenous versus hepatic intraarterial floxuridine in patients with colorectal cancer metastatic to the liver: the Northern California Oncology Group trial. J Clin Oncol 7:1646–1654Google Scholar
  9. 9.
    Kemeny N, Daly J, Reichman B, et al (1987) Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma. Ann Intern Med 107:459–465PubMedGoogle Scholar
  10. 10.
    Martin JK, O’Connel MJ, Wieand HS, et al (1990) Intraarterial floxuridine vs systemic fluorouracil for hepatic metastases from colorectal cancer. Arch Surg 125: 1022–1027PubMedCrossRefGoogle Scholar
  11. 11.
    Chang AE, Schneider PD, Sugarbaker PH, et al (1987) A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases. Ann Surg 206:685–693PubMedCrossRefGoogle Scholar
  12. 12.
    Kemeny MM, Goldberg D, Beatty JD, et al (1986) Results of a prospective randomized trial of continuous regional chemotherapy and hepatic resection as treatment of hepatic metastases from colorectal cancer. Cancer 57:492–498PubMedCrossRefGoogle Scholar
  13. 13.
    Rougier P, Laplanche A, Huguier M, et al (1992) Hepatic arterial infusion of floxuridine in patients with liver metastases from colorectal carcinoma: long-term results of prospective randomized trial. J Clin Oncol 10:1112–1118PubMedGoogle Scholar
  14. 14.
    Allen Mersh TG, Earlam S, Fordy C, et al (1994) Quality of life and survival with continuous hepatic artery floxuridine infusion for colorectal liver metastases. Lancet 344:1255–1260PubMedCrossRefGoogle Scholar
  15. 15.
    Patt YZ (1991) Regional hepatic arterial chemotherapy for colorectal cancer metastatic to the liver: the controversy continues. J Clin Oncol 11:815–819Google Scholar
  16. 16.
    Meta-Analysis Group in Cancer (1996) Reappraisal of hepatic arterial infusion in the treatment of nonresectable liver metastases from colorectal cancer. J Natl Cancer Inst 88:252–258CrossRefGoogle Scholar

Copyright information

© Springer Japan 1999

Authors and Affiliations

  • Yasuaki Arai
    • 1
  1. 1.Department of Diagnostic RadiologyAichi Cancer CenterNagoyaJapan

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