Computational Mechanical Model Studies in the Cardiovascular System
Historically, computational methods are the third avenue of the sciences, but this approach is now one of the most important, paralleling experimental and theoretical approaches. It has already been adopted in many fields of engineering and is regarded as a sine qua non tool for industrial design and manufacturing. Although its application in the fields of medicine and biology has so far been limited, the use of computational methods can be extended to wide areas of medical practice. In addition, the explosion of Internet technology will undoubtedly enhance and accelerate the development of biological and medical applications of computational mechanics. This article discusses a broad spectrum of computational approaches that can widen the horizon of computational biomechanics, and focuses on recent realistic models and simulations in the field of cardiovascular medicine.
KeywordsAcute Coronary Syndrome Computational Fluid Dynamic Wall Shear Stress Computational Mechanic Shear Stress Distribution
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- Becker RC (1999) Linking biochemical, pathologic, and clinical evetns in acuter coronary syndromes. In: Cannon CP (ed) Contemporary Cardiology: Management of Acute Coronary Syndromes, Humana Press, Totowa, New Jersey, pp 19–56Google Scholar
- Davies PF (1995) Flow-mediated endothelial mechanotransduction, Physiol Rev 75: 519–60Google Scholar
- Ministry of Health and Welfare, Japan (1999) Annual Report on Health and Welfare, White Paper, Japanese Government Printing Office, Tokyo, p. 341Google Scholar
- Sakurai A, Nakano A, Yamaguchi T, Masuda M, and Fujiwara K (1991) A computational fluid mechanical study of flow over cultured endothelial cells. Advances in Bioengineering (ASME) BED-20: 229–302Google Scholar
- Yamaguchi T(1996) Computational visualization of blood flow in the cardiovascular system In: Biological Flows, Jaffrin MY and Caro CG (eds) Plenum Press, New York pp. 115–136Google Scholar
- Yamaguchi T(1999) Flow and structure interactions in the cardiovascular system. In: Biomechanics: Numerical Simulation, (In Japanese) JSME (ed) Corona-sha, Tokyo pp. 10–36Google Scholar
- Yamaguchi T, Hoshiai K, Okino H, Sakurai A, Hanai S, Masuda M, and Fujiwara K(1993) Shear stress distribution over confluently cultured endothelial cells studied by computational fluid mechanics, ASME 1993 Bioengineering Conference, BED-24: 167–170.Google Scholar
- Yamaguchi T and Kobayashi T(1997) Computational Mechanics of Blood Flow and Arterial Wall Interactions - Effect of Wall Mechanical Properties, Advances In Bioengineering, BED-Vol. 36:107–108Google Scholar
- Yamaguchi T, Nakayama T, and Kobayashi T(1996) Computations of the Wall Mechanical Response under Unsteady Flows in Arterial Diseases, Advances in Bioengineering, BED-Vol. 33: 369–370Google Scholar
- Yamamoto Y and Yamaguchi T(1995) Spontaneous alignment of a three-dimensional model of cultured endothelial cells under steady flow conditions studied by computational fluid mechanics as an emergent system, J Japan Soc Biol Eng Med Elec 33:352–364.Google Scholar
- Yamamoto Y and Yamaguchi T(1996) Spontaneous alignment of a three-dimensional model of cultured endothelial cells under non-uniform and unsteady flow conditions studied by computational fluid mechanics as an emergent system, J Japan Soc Biol Eng Med Elec 34:274–278.Google Scholar
- Yoshida Y, Oyama T, Wang S,.Yamane T, Mitsumata M, Yamaguchi T, and Ooneda G (1988) Underlying morphological changes in the arterial wall at bifurcations for atherogenesis In: Role of Blood Flow in Atherogenesis, Yoshida Y, Yamaguchi T, Caro CG, Glagov S, Nerem RM (eds) Springer-Verlag, Tokyo pp. 33 - 40Google Scholar