Skip to main content
SpringerLink
Log in

Antiepileptic Drugs in the Treatment of Psychiatric Diseases

  • Conference paper
Contemporary Neuropsychiatry

  • 234 Accesses

Abstract

In the last two decades, antiepileptic drugs (AEDs) have been used for the management of psychiatric disorders. Their greatest use has been in the management of bipolar disorders, although more recent studies have demonstrated the efficacy of AEDs in anxiety disorders, unipolar depression, and the process of detoxifying patients from alcohol and cocaine. In this chapter, we briefly review the evidence in support of the use of AEDs in psychiatric disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Dalby MA (1971) Antiepileptic and psychotropic effect of carbamazepine (Tegretoi) in the treatment of psychomotor epilepsy. Epilepsia 12:325–334

    Article  PubMed  CAS  Google Scholar 

  2. Okuma T (1983) Therapeutic and prophylactic effects of carbamazepine in bipolar disorders. Psychiatr Clin N Am 6:157–174

    CAS  Google Scholar 

  3. Takezaki H, Hanaoka M (1971) The use of carbamazepine (Tegretol) in the control of manic-depressive psychosis and other manic-depressive states. Clin Psychiatry 13:173–183

    Google Scholar 

  4. Ballenger JC, Post RM (1980) Carbamazepine in manic-depressive illness: a new treatment. Am J Psychiatry 137:782–790

    PubMed  CAS  Google Scholar 

  5. Okuma T, Kazutoyo I, Otsuki S, et al (1981) A preliminary double-blind study on the efficacy of carbamazepine in prophylaxis of manic-depressive illness. Psychopharmacology 73:95–96

    Article  PubMed  CAS  Google Scholar 

  6. Post RM, Uhde TW, Ballenger JC, et al (1983) Prophylactic efficacy of carbamazepine in manic-depressive illness. Am J Psychiatry 140:1602–1604

    PubMed  CAS  Google Scholar 

  7. Placidi GF, Lenzi A, Lazzerini F, et al (1986) The comparative efficacy and safety of carbamazepine versus lithium: a randomized, double-blind 3-year trial in 83 patients. J Clin Psychiatry 47:490–494

    PubMed  CAS  Google Scholar 

  8. Watkins SE, Callender K, Thomas DR, et al (1987) The effect of carbamazepine and lithium on remission from affective illness. Br J Psychiatry 150:180–182

    Article  PubMed  CAS  Google Scholar 

  9. Lusznat RM, Murphy DP, Nunn CM (1988) Carbamazepine vs.lithium in the treatment and prophylaxis of mania. Br J Psychiatry 153:198–204

    Article  PubMed  CAS  Google Scholar 

  10. Small JG, Klapper MH, Milstein V, et al (1991) Carbamazepine compared with lithium in the treatment of mania. Arch Gen Psychiatry 48:915–921

    Article  PubMed  CAS  Google Scholar 

  11. Coxhead N, Silverstone T, Cookstone J (1992) Carbamazepine versus lithium in the prophylaxis of bipolar affective disorder. Acta Psychiatr Scand 85:114–118

    Article  PubMed  CAS  Google Scholar 

  12. Simhandl C, Denk E, Thau K (1993) The comparative efficacy of carbamazepine low and high serum levels and lithium carbonate in the prophylaxis of affective disorders. J Affect Disord 28:221–231

    Article  PubMed  CAS  Google Scholar 

  13. Denicoff KD, Smith-Jackson EE, Disney ER, et al (1997) Comparative prophylactic efficacy of lithium, carbamazepine, and the combination in bipolar disease. J Clin Psychiatry 58:470–478

    Article  PubMed  CAS  Google Scholar 

  14. Greil W, Ludwig-Mayerhofer W, Erazo N, et al (1997) Lithium versus carbamazepine in the maintenance treatment of bipolar disorders-a randomized study. J Affect Disord 43:151–161

    Article  PubMed  CAS  Google Scholar 

  15. Kishimoto A, Ogura C, Hazama H, et al (1983) Long-term prophylactic effects of carbamazepine in affective disorder. Br J Psychiatry 143:327–331

    Article  PubMed  CAS  Google Scholar 

  16. Nolen WA (1983) Carbamazepine: a possible adjunct or alternative to lithium in bipolar disorders. Acta Psychiatr Scand 67:218–225

    Article  PubMed  CAS  Google Scholar 

  17. Folks DG, King LD, Dowdy SB, et al (1982) Carbamazepine treatment of selected affectively disordered inpatients. Am J Psychiatry 139: 115–117

    PubMed  CAS  Google Scholar 

  18. Lipinski JF, Pope HA (1982) Possible synergistic action between carbamazepine and lithium carbonate in the treatment of three acutely manic patients. Am J Psychiatry 139:948–949

    PubMed  CAS  Google Scholar 

  19. Keisling R (1983) Carbamazepine and lithium carbonate in the treatment of refractory affective disorders. Arch Gen Psychiatry 40:223

    Article  PubMed  CAS  Google Scholar 

  20. Warren JA, Crismon ML (1982) Carbamazepine in bipolar disorder-mixed. Clin Pharmacoll:266–268

    Google Scholar 

  21. Fritze J, Beneke M, Lanczik M, et al (1994) Carbamazepine as adjunct or alternative to lithium in the prophylaxis of recurrent affective disorders. Pharmacopsychiatry 27:181–185

    Article  PubMed  CAS  Google Scholar 

  22. Calabrese JR, Delucchi GA (1990) Spectrum of efficacy of valproate in 55 patients with rapid-cycling bipolar disorder. Am J Psychiatry 147:431–434

    PubMed  CAS  Google Scholar 

  23. Deltito JA Levitan J, Damore J, et al (1998) Naturalistic experience with the use of divalproex sodium on an inpatient unit for adolescent psychiatric patients. Acta Psychiatr Scand 97:236–240

    Article  PubMed  CAS  Google Scholar 

  24. Keck PE, McElroy SL, Tugrul KC, et al (1993) Valproate oral loading in the treatment of acute mania. J Clin Psychiatry 54:305–308

    PubMed  Google Scholar 

  25. McElroy SL, Keck PE, Stanton SP, et al (1996) A randomized comparison of divalproex oral loading versus haloperidol in the initial treatment of acute psychotic mania. J Clin Psychiatry 57:142–146

    PubMed  CAS  Google Scholar 

  26. Papatheodorou G, Kutcher SP, Katic M, et al (1995) The efficacy and safety of divalproex sodium in the treatment of acute mania in adolescents and young adults: an open clinical trial. J Clin Psychopharmacol 15:110–116

    Article  PubMed  CAS  Google Scholar 

  27. Pope HG, McElroy SL, Keck PE, et al (1991) Valproate in the treatment of acute mania. Arch Gen Psychiatry 48:62–68

    Article  PubMed  Google Scholar 

  28. Bowden CL, Brugger AM, Swann AC, et al (1994) Efficacy of divalproex vs.lithium and placebo in the treatment of mania. JAMA 271:918–924

    Article  PubMed  CAS  Google Scholar 

  29. Freeman TW, Clothier JL, Pazzaglia P, et al (1992) A double-blind comparison of valproate and lithium in the treatment of acute mania. Am J Psychiatry 149: 108–111

    PubMed  CAS  Google Scholar 

  30. Emrich HM, Dose M, Vonzerssen D (1985) The use of sodium valproate, carbamazepine, and oxcarbazepine in patients with affective disorders. J Affect Disord 8:243–250

    Article  PubMed  CAS  Google Scholar 

  31. Herbert P.B., Nelson JC (2000) Parenteral valproate for control of acute mania (letter). Am J Psychiatry 157:1023–1024

    Article  PubMed  CAS  Google Scholar 

  32. Norton JW, Quarles E (2000) Intravenous valproate in neuropsychiatry. Pharmacotherapy 20:88–92

    Article  PubMed  CAS  Google Scholar 

  33. Solomon DA, Ryan CE, Keitner GI, et al (1997) A pilot study of lithium carbonate plus divalproex sodium for the continuation and maintenance treatment of patients with bipolar I disorder. J Clin Psychiatry 58:95–99

    Article  PubMed  CAS  Google Scholar 

  34. Bowden CL, Calabrese JR, McElroy SL, et al (2000) A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Arch Gen Psychiatry 57:481–489

    Article  PubMed  CAS  Google Scholar 

  35. Ryback RS, Brodsky L, Munasifi F (1997) Gabapentin in bipolar disorder (letter). J Neuropsychiat Clin Neurosci 9:301

    CAS  Google Scholar 

  36. Stanton SP, Keck PE Jr, McElroy SL (1997) Treatment of acute mania with gabapentin (letter). Am J Psychiatry 154:287

    PubMed  CAS  Google Scholar 

  37. Bennett J, Goldman W, Suppes T (1997) Gabapentin for treatment of bipolar and schizo affective disorders (letter). J Clin Psychopharmacol 17:141–142

    Article  PubMed  CAS  Google Scholar 

  38. Schaffer CB, Schaffer LC (1999) Open maintenance treatment of bipolar disorder spectrum patients who responded to gabapentin augmentation in the acute phase of treatment. J Affect Disord 55:237–240

    Article  PubMed  CAS  Google Scholar 

  39. Ghaemi SN, Katzow JJ, Desai SP, et al (1998) Gabapentin treatment of mood disorders: a preliminary study. J Clin Psychiatry 59:426–429

    Article  PubMed  CAS  Google Scholar 

  40. Young LT, Robb JC, Hasey GM, et al (1999) Gabapentin as an adjunctive treatment in bipolar disorder. J Affect Disord 55:73–77

    Article  PubMed  CAS  Google Scholar 

  41. Sporn J, Sachs G (1997) The anticonvulsant lamotrigine in treatment-resistant manic-depressive illness. J Clin Psychopharmacol 17:185–189

    Article  PubMed  CAS  Google Scholar 

  42. Kusumakar V, Yatham LN (1997) An open study of lamotrigine in refractory bipolar depression. Psychiatry Res 72: 145–148

    Article  PubMed  CAS  Google Scholar 

  43. Fatemi SH, Rapport DJ, Calabrese JR, et al (1997) Lamotrigine in rapid-cycling bipolar disorder. J Clin Psychiatry 58:522–527

    Article  PubMed  CAS  Google Scholar 

  44. Calabrese JR, Bowden CL, Sachs GS, et al (1999) A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. J Clin Psychiatry 60:79–88

    Article  PubMed  CAS  Google Scholar 

  45. Marcotte D (1998) Use of topiramate: a new anti-epileptic as a mood stabilizer. J Affect Disord 50:245–251

    Google Scholar 

  46. Post RM, Uhde TW, Roy-Byrne PP, et al (1986) Antidepressant effects of carbamazepine. Am J Psychiatry 143:29–34

    PubMed  CAS  Google Scholar 

  47. Kemp LI (1992) Sodium valproate as an antidepressant. Br J Psychiatry 160:121–123

    Article  PubMed  CAS  Google Scholar 

  48. Pies R, Adler DA, Ehrenberg BL (1989) Sleep disorders and depression with atypical features: response to valproate. J Clin Psychopharmacol 9:352–357

    Article  PubMed  CAS  Google Scholar 

  49. Davis LL, Kabel D, Patel D, et al (1996) Valproate as an antidepressant in major depressive disorder. Psychopharmacol Bull 32:647–652

    PubMed  CAS  Google Scholar 

  50. Primeau F, Fontaine R, Beaclair L (1990) Valproic acid and panic disorder. Can J Psychiatry 35:248–250

    PubMed  CAS  Google Scholar 

  51. Woodman CL, Noyes R (1994) Panic disorder: treatment with valproate. J Clin Psychiatry 55:134–136

    PubMed  CAS  Google Scholar 

  52. Lum M, Fontaine R, Elie R, et al (1991) Probable interaction of sodium divalproex with benzodiazepines. Prog Neuropsychopharmacol Biol Psychiatry 15:269–273

    Article  PubMed  CAS  Google Scholar 

  53. Chouinard G, Beauclair L, Belanger MC (1998) Gabapentin: long-term antianxiety and hypnotic effects in psychiatric patients with comorbid anxiety-related disorders. Can J Psychiatry 43:305

    PubMed  CAS  Google Scholar 

  54. Pollack MG, Matthews J, Scott EL (1998) Gabapentin as a potential treatment for anxiety disorders. Am J Psychiatry 155:992–993

    PubMed  CAS  Google Scholar 

  55. Pande AC, Davidson JR, Jefferson JW, et al (1999) Treatment of social phobia with gabapentin: a placebo-controlled study. J Clin Psychopharmacol 19:341–348

    Article  PubMed  CAS  Google Scholar 

  56. Uhde TW, Stein MB, Post RM (1988) Lack of efficacy of carbamazepine in the treatment of panic disorder. Am J Psychiatry 145: 1104–1109

    PubMed  CAS  Google Scholar 

  57. Lambie DG, Johnson RH, Vijayasenan M.E., et al (1980) Sodium valproate in the treatment of the alcohol withdrawal syndrome. Aust N Z J Psychiatry 14:213–215

    Article  PubMed  CAS  Google Scholar 

  58. Rosenthal RN, Perkel C, Singh P, et al (1998) A pilot open randomized trial of valproate and phenobarbital in the treatment of acute alcohol withdrawal. Am J Addict 7: 189–197

    PubMed  CAS  Google Scholar 

  59. Hammer BA, Brady KT (1996) Valproate treatment of alcohol withdrawal and mania (letter). Am J Psychiatry 153:1232

    PubMed  CAS  Google Scholar 

  60. Rickels K, Schweizer E, Garcia Espana F, et al (1999) Trazadone and valproate in patients discontinuing long-term benzodiazepine therapy: effects of withdrawal symptoms and taper outcome. Psychopharmacology 141:1–5

    Article  PubMed  CAS  Google Scholar 

  61. Ries RK, Roy-Byrne PP, Ward N.G., et al (1989) Carbamazepine treatment for benzodiazepine withdrawal. Am J Psychiatry 146:536–537

    PubMed  CAS  Google Scholar 

  62. Montoya ID, Levin FR, Fudala PJ, et al (1995) Double-blind comparison of carbamazepine and placebo for treatment of cocaine dependence. Drug Alcohol Dependence 38:213–219

    Article  CAS  Google Scholar 

  63. Cornish JW, Maany I, Fudala PJ, et al (1995) Carbamazepine treatment for cocaine dependence. Drug Alcohol Dependence 38:221–227

    Article  CAS  Google Scholar 

  64. Kranzler HR, Bauer LO, Hersh D (1995) Carbamazepine treatment of cocaine dependence: a placebo-controlled trial. Drug Alcohol Dependence 38:203–211

    Article  CAS  Google Scholar 

  65. Donovan SJ, Stewart JW, Nunes EV, et al (2000) Divalproex treatment for youth with explosive temper and mood lability: a double-blind, placebo-controlled crossover design. Am J Psychiatry 157:818–820

    Article  PubMed  CAS  Google Scholar 

  66. Kavoussi RJ, Coccaro EF (1998) Divalproex sodium for impulsive aggressive behavior in patients with personality disorder. J Clin Psychiatry 59:676–680

    Article  PubMed  CAS  Google Scholar 

  67. Daly KA, Fatemi SH (1999) Lamotrigine and impulse behaviour (letter). Can J Psychiatry 44:395–396

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurological Sciences, Rush-Presbyterian-St. Luke’s Medical Center, 1653 W. Congress Parkway, Chicago, IL, 60612, USA

    Andres M. Kanner & Susan Palac

Authors
  1. Andres M. Kanner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Susan Palac
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Psychiatry, Kyoto University Graduate School of Medicine, 520 Saisho-Koh, Sakyo, Kyoto, 606-8397, Japan

    Koho Miyoshi (Former Professor) (Former Professor)

  2. The Toronto Hospital, Department of Psychiatry, University of Toronto, 399 Bathurst Street, Toronto, Ontario, M5T 2S8, Canada

    Colin M. Shapiro (Professor) (Professor)

  3. Division of Neuropsychiatry, Department of Psychiatry, University of Illinois at Chicago, 912 S. Wood Street, Chicago, IL, 60612, USA

    Moises Gaviria (Professor) (Professor)

  4. Hyogo Medical University, 1-1 Mukogawa, Nishinomiya, Hyogo, 663-8501, Japan

    Yoshio Morita (Professor) (Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Japan

About this paper

Cite this paper

Kanner, A.M., Palac, S. (2001). Antiepileptic Drugs in the Treatment of Psychiatric Diseases. In: Miyoshi, K., Shapiro, C.M., Gaviria, M., Morita, Y. (eds) Contemporary Neuropsychiatry. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67897-7_64

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-67897-7_64

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67992-9

  • Online ISBN: 978-4-431-67897-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation