Anticonvulsants in Neuropsychiatry

  • Moises Gaviria
  • David Medina
Conference paper


The effects that antiepileptic drugs (AEDs) have on the neural membrane and on neurotransmitter receptors give these agents invaluable properties for treatment of a broad variety of neuropsychiatric disorders in addition to seizures and neuropathic pain [17]. Accordingly, AEDs should be more accurately considered as neuromodulatory drugs than strictly as anticonvulsants.


Bipolar Disorder Anxiety Disorder Mood Disorder Personality Disorder Social Phobia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Beijamini V, Skalisz LL, Joca SR, Andreatini R (1998) The effect of oxcarbazepine on behavioural despair and learned helplessness. Eur J Pharmacol 347:23–27PubMedCrossRefGoogle Scholar
  2. 2.
    Botts SR, Raskind J (1999) Gabapentin and lamotrigine in bipolar disorder. Am J Health Syst Pharm 56:1939–1944PubMedGoogle Scholar
  3. 3.
    Bowden CL, Calabrese JR, Mc Elroy SL, et al (1999) The efficacy of lamotrigine in rapid cycling and non-rapid cycling patients with bipolar disorder. Biol Psychiatry 45:953–958PubMedCrossRefGoogle Scholar
  4. 4.
    Cabras PL, Hardoy MJ, Hardoy MC, Carta MG (1999) Clinical experience with gabapentin in patients with bipolar or schizoaffective disorder: results of an open-label study. J Clin Psychiatry 60:245–248PubMedCrossRefGoogle Scholar
  5. 5.
    Calabrese JR, Bowden CL, McElroy SL, et al (1999) Spectrum of activity of lamotrigine in treatment-refractory bipolar disorder. Am J Psychiatry 156:1019–1023PubMedGoogle Scholar
  6. 6.
    Calabrese JR, Bowden CL, Sacks GS, et al (1999) A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression: Lamictal 602 study group. J Clin Psychiatry 60:79–88PubMedCrossRefGoogle Scholar
  7. 7.
    Calabrese JR, Rapport DJ, Kimmel SE, Shelton MD (1999) Controlled trials in bipolar I depression: focus on switch rates and efficacy. Eur Neuropsychopharmacol 9 (suppl 4):S109–S112PubMedCrossRefGoogle Scholar
  8. 8.
    Calabrese JR, Rapport DJ, Shelton MD, et al (1998) Clinical studies on the use of lamotrigine in bipolar disorder. Neuropsychobiology 38:185–191PubMedCrossRefGoogle Scholar
  9. 9.
    Chouinard G, Beauclair L, Belanger MC (1998) Gabapentin: long-term antianxiety and hypnotic effects in psychiatric patients with comorbid anxiety-related disorders. Can J Psychiatry 43:305PubMedGoogle Scholar
  10. 10.
    Connor KM, Davidson JR, Sutherland S, Weisler R (1999) Social phobia: issues in assessment and management. Epilepsia 40 (suppl 6):S60–S65PubMedCrossRefGoogle Scholar
  11. 11.
    Dilsaver SC, Swann SC, Chen Y.W., et al (1996) Treatment of bipolar depression with carbamazepine: results of an open study. Biol Psychiatry 40:935–937PubMedCrossRefGoogle Scholar
  12. 12.
    Emrich HM, Dose M, von Zerssen D (1985) The use of sodium valproate, carbamazepine and oxcarbamazepine in patients with affective disorders. J Affect Disord 8:243–250PubMedCrossRefGoogle Scholar
  13. 13.
    Erfurth A, Kammerer C, Grunze H, Normann C, Walden J (1998) An open label study of gabapentin in the treatment of acute mania. J Psychiatr Res 32:261–264PubMedCrossRefGoogle Scholar
  14. 14.
    Ferrier IN (1998) Lamotrigine and gabapentin: alternative in the treatment of bipolar disorders. Neuropsychobiology 38:192–197PubMedCrossRefGoogle Scholar
  15. 15.
    Gordon A, Price LH (1999) Mood stabilization and weight loss with topiramate [letter]. Am J Psychiatry 156:968–969PubMedGoogle Scholar
  16. 16.
    Grunze H, Erfurth A, Amman B, et al (1999) Intravenous valproate loading in acutely manic and depressed bipolar I patients. J Clin Psychopharmacology 19:303–309CrossRefGoogle Scholar
  17. 17.
    Ketter TA, Post RM, Theodore WH (1999) Positive and negative psychiatric effects of antiepileptic drugs in patients with seizure disorders. Neurology 53 (5 suppl 2):S53–S67PubMedGoogle Scholar
  18. 18.
    Kosten TR (1998) The pharmacotherapy of relapse prevention using anticonvulsants. Am J Addict 7:205–209PubMedGoogle Scholar
  19. 19.
    Letterman L, Markowitz JS (1999) Gabapentin: a review of published experience in the treatment of bipolar disorder and other psychiatric conditions. Pharmacotherapy 19:565–572PubMedCrossRefGoogle Scholar
  20. 20.
    Marcotte D (1998) Use of topiramate, a new anti-epileptic as a mood stabilizer. J Affect Disord 50:245–251PubMedCrossRefGoogle Scholar
  21. 21.
    McElroy SL, Soutullo CA, Keck PE Jr, Kmetz GF (1997) A pilot trial of adjunctive gabapentin in the treatment of bipolar disorder. Ann Clin Psychiatry 9:99–103PubMedGoogle Scholar
  22. 22.
    Normann C, Langosch J, Schaerer LO, et al (1999) Treatment of acute mania with topiramate [letter]. Am J Psychiatry 156:2014PubMedGoogle Scholar
  23. 23.
    Pande AC, Davidson JR, Jefferson JW, et al (1999) Treatment of social phobia with gabapentin: a placebo-controlled study. J Clin Psychopharmacol 19:341–348PubMedCrossRefGoogle Scholar
  24. 24.
    Perugi G, Toni C, Ruffolo G, et al (1999) Clinical experience using adjunctive gabapentin in treatment-resistant bipolar mixed states. Pharmacopsychiatry 32:136–141PubMedCrossRefGoogle Scholar
  25. 25.
    Pinto OC, Akiskal HS (1998) Lamotrigine as a promising approach to borderline personality: an open case series without concurrent DSM-IV major mood disorder. J Affect Disord 51:333–334PubMedCrossRefGoogle Scholar
  26. 26.
    Pollack MH, Matthews J, Scott EL (1998) Gabapentin as a potential treatment for anxiety disorders [letter]. Am J Psychiatry 155:992–993PubMedGoogle Scholar
  27. 27.
    Post RM, Ketter TA, Denicoff K, et al (1996) The place of anticonvulsivant therapy in bipolar illness. Psychopharmacology (Berl) 128:115–129CrossRefGoogle Scholar
  28. 28.
    Sackellares JC, Berent S (1996) Psychological disturbances in epilepsy. Butterworth-Heinemann, Boston, 219–245Google Scholar
  29. 29.
    Schaffer CB, Schaffer LC (1999) Open maintenance treatment of bipolar disorder spectrum patients who responded to gabapentin augmentation in the acute phase of treatmen. J Affect Disord 55:237–240PubMedCrossRefGoogle Scholar
  30. 30.
    Singh L, Field MJ, Ferris P, et al (1996) The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine. Psychopharmacology (Berl) 127:1–9CrossRefGoogle Scholar
  31. 31.
    Sokolski KN, Green C, Maris DE, DeMet EM (1999) Gabapentin as an adjunct to standard mood stabilizers in outpatients with mixed bipolar symptomatology. Ann Clin Psychiatry 11:217–222PubMedGoogle Scholar
  32. 32.
    Suppes T, Brown ES, McElroy SL, et al (1999) Lamotrigine for the treatment of bipolar disorder: a clinical case series. J Affect Disord 53:95–98PubMedCrossRefGoogle Scholar
  33. 33.
    Trimble MR (1998) New antiepileptic drugs and psychopathology. Neuropsychobiology 38:149–151PubMedCrossRefGoogle Scholar
  34. 34.
    Watson WP, Robinson E, Little HJ (1997) The novel anticonvulsant, gabapentin, protects against both convulsant and anxiogenic aspects of the ethanol withdrawal syndrome. Neuropharmacology 36:1369–1375PubMedCrossRefGoogle Scholar
  35. 35.
    Windhaber J, Maierhofer D, Dantendorfer K (1997) Oxcarbazepine for panic disorder occurring after two grand mal seizures: a case report [letter]. J Clin Psychiatry 58:404–405PubMedCrossRefGoogle Scholar
  36. 36.
    Young LT, Robb JC, Hasey GM, et al (1999) Gabapentin as an adjunctive treatment in bipolar disorder. J Affect Disord 55:73–77PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 2001

Authors and Affiliations

  • Moises Gaviria
    • 1
  • David Medina
    • 1
  1. 1.Neuropsychiatric Division, Department of PsychiatryUniversity of Illinois at ChicagoChicagoUSA

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