Effects of Antidepressants and Lithium on Intracellular Calcium Signaling
It is well known that calcium ions (Ca2+) play a crucial role in the growth and maintenance of basic cellular functions in the central nervous system (CNS). Several technical developments have contributed to the measurement of cytosolic Ca2+ in living cells. Since the most effective fluorescent dye, fura-2, and its acetoxymethyl ester derivative were developed, many studies have been performed to determine if there is an abnormal function in cytosolic Ca2+ concentration in living cells. In the field of biological psychiatry, many researchers have investigated intracellular Ca2+ concentration ([Ca2+]i) using human platelets, a model of the neuron. In this chapter, we review recent advances in the investigation of Ca2+ in bipolar disorders from both clinical and basic perspectives.
KeywordsBipolar Disorder Mood Disorder Mood Stabilizer Bipolar Affective Disorder Bipolar Disorder Patient
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- 5.Okamoto Y, Kagaya A, Shinno H, et al (1995) Serotonin-induced platelet calcium mobilization is enhanced in mania. Life Sci 56:R2Google Scholar