Abstract
Helicobacter pylori (Hp) lipopolysaccharide (LPS) is generally considered to have low toxic virulence. However, when guinea pig pit cells were cultured under LPS-free conditions and treated with various concentrations of Hp LPS, low concentrations of Hp LPS (>2.1 endotoxin unit/ml) stimulated apoptosis of the cultured pit cells, and this apoptosis was induced by lipid A region of Hp LPS. Hp LPS caused activation of caspase 3, DNA fragmentation, and the appearance of nuclear condensation of the cells. Epidermal growth factor suppressed the Hp LPS-induced apoptosis. These results suggest that Hp LPS may play an important role in the pathogenesis of Hp infection.
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References
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© 2001 Springer Japan
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Kawahara, T., Teshima, S., Kishi, K., Rokutan, K. (2001). Epidermal Growth Factor Inhibits Helicobacter pylori Lipopolysaccharide-Induced Apoptosis of Primary Cultures of Gastric Pit Cells. In: Asakura, H., Aoyagi, Y., Nakazawa, S. (eds) Trends in Gastroenterology and Hepatology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67895-3_5
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DOI: https://doi.org/10.1007/978-4-431-67895-3_5
Publisher Name: Springer, Tokyo
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