Abstract
This paper updates concepts on the role of cyclooxygenase (COX) in tissue inflammation. An inducible isoform of cyclooxygenase is expressed in various cell types by inflammatory promoters, mitogens, cytokines, their receptors, and pathogenic factors such as Helicobacter. Overexpressed COX-2 has been believed to serve as a proinflammatory enzyme that increases prostaglandin production and causes swelling, pain, and hyperemia. Recent data indicate that certain prostaglandins suppress immune responses and inflammatory cell infiltration. To test the hypothesis that COX-2 acts as antiinflammatory enzyme in a certain aspect, we examined the effects of specific and nonspecific COX-2 inhibitors on gastric mucosa. The results demonstrate that COX-2 inhibition activates inflammatory cell infiltration. Thus, the inducible isoform of cyclooxygenase may have antiinflammatory properties in the stomach.
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© 2001 Springer Japan
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Tsuji, S., Sun, WH., Tsujii, M., Kawano, S., Hori, M. (2001). Does Cyclooxygenase-2 Down-Regulate Gastric Inflammation?. In: Asakura, H., Aoyagi, Y., Nakazawa, S. (eds) Trends in Gastroenterology and Hepatology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67895-3_14
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DOI: https://doi.org/10.1007/978-4-431-67895-3_14
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-67993-6
Online ISBN: 978-4-431-67895-3
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