Lysosomal Enzyme GlcNAc-1- Phosphotransferase

  • Atsushi Nishikawa


GlcNAc-1-Phosphotransferase (UDP-GlcNAc; lysosomal enzyme N-acetylglu- cosamine-1-phosphotransferase; EC number catalyzes the transfer of GlcNAc-1-phosphate from UDP-GlcNAc to the C-6 oxygen of selected mannose residues in high-mannose-type N-glycan. The product, mannose 6-phosphate (Man- 6-P), which is modified consecutively by N-acetylglucosamine-1-phosphodiester α-N- acetylglucosaminidase (see Chapter 89) is the specific tag for the sorting system of the lysosomal enzymes.


Lysosomal Enzyme Lysosomal Storage Disease Acid Hydrolase Lysosomal Hydrolase Secretory Glycoprotein 


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© Springer Japan 2002

Authors and Affiliations

  • Atsushi Nishikawa
    • 1
  1. 1.Department of Applied Biological ScienceTokyo University of Agriculture and TechnologyTokyoJapan

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