The Golgi and rough endoplasmic reticulum (ER) membranes have an activity that transports UDP-GlcNAc from the cytosol into their lumens (Perez and Hirschberg 1985; Bossuyt and Blanckaert 1994). The nucleotide sugar transported to the Golgi lumen serves as a substrate of GlcNAc transferases for the elongation of carbohydrate chains of glycoproteins, glycolipids, and proteoglycans. On the other hand, the reactions in which UDP-GlcNAc is utilized in the ER have not yet been definitively identified.
KeywordsEndoplasmic Reticulum Membrane Golgi Membrane Uridine Diphosphate Nucleotide Sugar Transporter Golgi Lumen
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