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UDP-Gal Transporter-1 and -2

  • Masao Kawakita
  • Nobuhiro Ishida

Abstract

UDP-Gal transporter is a multiple-segment transmembrane protein of the Golgi apparatus that delivers UDP-Gal, synthesized in the cytosol, into the Golgi lumen to provide various Gal transferases with their substrate for the elongation of carbohydrate chains (Kawakita et al. 1998). Gal transferases, whose catalytic sites face the Golgi lumen, cannot add Gal residues to growing carbohydrate chains unless UDP- Gal is supplied through UDP-Gal transporter. Thus, mutant cultured cell lines defective in UDP-Gal transporter were shown to accumulate Glc-Cer instead of lactosylceramide (Taki et al. 1991), and truncated Nl-inked oligosaccharide chains terminated at GlcNAc (Hara et al. 1989).

Keywords

Newcastle Disease Virus Golgi Membrane Mutant Cell Line Newcastle Disease Virus Infection Microsomal Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Masao Kawakita
    • 1
    • 2
  • Nobuhiro Ishida
    • 1
  1. 1.Department of Physiological ChemistryTokyo Metropolitan Institute of Medical ScienceTokyoJapan
  2. 2.Department of Applied ChemistryKogakuin UniversityTokyoJapan

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