Abstract
βGal 3-O-sulfotransferases (Gal3STs) are Golgi-membrane sulfotransferases catalyzing the transfer of a sulfate group from the donor substrate PAPS to the C3 position of the nonreducing terminal Gal residue of carbohydrate chains. Four Gal3STs have been identified so far and their primary structures are similar to each other (Honke et al. 1997; Honke et al. 2001; Suzuki et al. 2001; El-Fasakhany et al. 2001; Seko et al. 2001). The original Gal3ST gene was cloned as a gene that encodes cerebroside sul- fotransferase (CST) (Honke et al. 1997) based on the amino acid sequence of the purified enzyme (Honke et al. 1996). The second through fourth Gal3ST genes were very recently cloned by making use of homology to the CST gene (Honke et al. 2001; Suzuki et al. 2001; El-Fasakhany et al. 2001; Seko et al. 2001). Although the characteristics and biological function of CST have been extensively studied (Honke et al. 1997; Ishizuka 1997), reports on the other GaBSTs are limited. Therefore, I mainly focus on the original Gal3ST, CST, in this chapter.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Balbaa M, Honke K, Makita A (1996) Regulation of glycolipid sulfotransferase by tyrosine kinases in human renal cancer cells. Biochim Biophys Acta 1299:141–145
Brockhausen I, William K (1997) Trends Glycosci Glycotechnol 9:379–398
Capon C, Wieruszeski JM, Lemoine J, Byrd JC, Leffler H, Kim YS (1997) Sulfated Lewis x determinants as a major structural motif in glycans from LS174T-HM7 human colon carcinoma mucin. J Biol Chem 272:31957–31968
El-Fasakhany FM, Uchimura K, Kannagi R, Muramatsu T (2001) A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization and its implications in biosynthesis of 3′-sulfo Lewisx. J Biol Chem 276:26988–26994
Farooqui AA, Rebel G, Mandel P (1977) Sulphatide metabolism in brain. Life Sci 20:569–583
Feizi, T, Glaustian C (1999) Novel oligosaccharide ligands and ligand-processing pathways for the selectins. Trends Biochem Sci 24:369–372
Hakomori S (1985) Aberrant glycosylation in cancer cell membranes as focused on glycolipids: overview and prospectives. Cancer Res 45:2405–2414
Hirahara Y, Tsuda M, Wada Y, Honke K (2000) cDNA cloning, genomic cloning, and tissue-specific regulation of mouse cerebroside sulfotransferase. Eur J Biochem 267:1909–1916
Honke K, Tsuda M, Hirahara, Y, Ishii A, Makita A, Wada Y (1997) Molecular cloning and expression of cDNA encoding human 3′-phosphoadenylylsulfate:galactosylceramide 3′-sulfotransferase. J Biol Chem 272:4864–4868
Honke K, Tsuda M, Hirahara Y, Miyao N, Tsukamoto T, Satoh M, Wada Y (1998) Cancer-associated expression of glycolipid sulfotransferase gene in human renal cell carcinoma cells. Cancer Res 58:3800–3805
Honke K, Tsuda M, Koyota S, Wada Y, Tanaka N, Ishizuka I, Nakayama J, Taniguchi N (2001) Molecular cloning and characterization of a human β-Gal 3′-sulfotransferase which acts on both type 1 and type 2 (Galβ1,3/l,4GlcNAc-R) oligosaccharides. J Biol Chem 276:267–274
Honke K, Yamane M, Ishii A, Kobayashi T, Makita A (1996) Purification and characterization of 3′-phosphoadenosine-3′-phosphosulfate:GalCer sulfotransferase from human renal cancer cells. J Biochem 119:421–427
Ikeda N, Eguchi H, Nishihara S, Narimatsu H, Kannagi R, Irimura T, Ohta M, Matsuda H, Taniguchi N, Honke K (2001) A remodeling system of 3′-sulfo Lewis a and 3′-sulfo Lewis x epitopes. J Biol Chem (in press)
Ishizuka I (1997) Chemistry and functional distribution of sulfoglycolipids. Prog Lipid Res 36:245–319
Izawa M, Kumamoto K, Mitsuoka C, Kanamori A, Ohmori K, Ishida H, Nakamura S, Kurata-Miura K, Sasaki K, Nishi T, Kannagi R (2000) Expression of sialyl 6-sulfo Lewis x is inversely correlated with conventional sialyl Lewis x expression in human colorectal cancer. Cancer Res 60:1410–1416
Kawano M, Honke K, Tachi M, Gasa S, Makita A (1989) An assay method for ganglioside synthase using anion-exchange chromatography. Anal Biochem 182:9–15
Kobayashi T, Honke K, Gasa S, Imai S, Tanaka J, Miyazaki T, Makita A (1993a) Regulation of activity levels of glycolipid sulfotransferases by transforming growth factor a in renal cell carcinoma cells. Cancer Res. 53:5638–5642
Kobayashi T, Honke K, Gasa S, Kato N, Miyazaki T, Makita A (1993b) Epidermal growth factor elevates the activity levels of glycolipid sulfotransferases in renα1-cell-carcinoma cells. Int J Cancer 55:448–452
Kobayashi T, Honke K, Gasa S, Sugiura M, Miyazaki T, Ishizuka I, Makita A (1993c) Involvement of protein kinase C in the regulation of glycolipid sulfotransferase activity levels in renal cell carcinoma cells. Cancer Res. 53:2484–2489
Kobayashi T, Honke K, Kamio K, Sakakibara N, Gasa S, Miyao N, Tsukamoto T, Ishizuka I, Miyazaki T, Makita A (1993d) Sulfolipids and glycolipid sulfotransferase activities in human renal cell carcinoma cells. Br J Cancer 67:76–80
Kobayashi T, Honke K, Gasa S, Miyazaki T, Tajima H, Matsumoto K, Nakamura T, Makita A (1994) Hepatocyte growth factor elevates the activity levels of glycolipid sulfotransferases in renal cell carcinoma cells. Eur J Biochem. 219:407–413
Lingwood CA (1985) Developmental regulation of galactoglycerolipid and galactosphin-golipid sulphation during mammalian spermatogenesis. Biochem J 231:393–400
Sakakibara N, Gasa S, Kamio K, Makita A, Koyanagi T (1989) Association of elevated sulfatides and sulfotranasferase activities with human renal cell carcinoma. Cancer Res 49:335–339
Seko A, Hara-Kuge S, Yamashita K (2001) Molecular cloning and characterization of a novel human galactose 3-O-sulfotransferase that transfers sulfate to Galβ1-3GalNAc residue in O-glycans. J Biol Chem 276:25697–25704
Suzuki A, Hiraoka N, Suzuki M, Angata K, Misra AK, McAuliffe J, Hindsgaul O, Fukuda M (2001) Molecular cloning and expression of a novel human β-Gal-3-O-sulfotrans-ferase that acts preferentially on N-acetyllactosamine in N-and O-glycans. J Biol Chem 276:24388–24395
Tennekoon G, Aitchison S, Zaruba M (1985) Purification and characterization of galacto-cerebroside sulfotransferase from rat kidney. Arch Biochem Biophys 240:932–944
Tsuda M, Egashira M, Niikawa N, Wada Y, Honke K (2000) Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene. Eur J Biochem 267:2672–2679
Vavasseur F, Dole K, Yang J, Matta KL, Myerscough N, Cornfield A, Paraskeva C, Brock-hausen I (1994) O-Glycan biosynthesis in human colorectal adenoma cells during progression to cancer. Eur J Biochem 222:415–424
Vos JP, Lopes-Cardozo M, Gadella BM (1994) Metabolic and functional aspects of sulfogalactolipids. Biochim Biophys Acta 1211:125–149
Yabunaka N, Honke K, Ishii A, Ogiso Y, Kuzumaki N, Agishi Y, Makita A (1997) Involvement of Ras in the expression of glycolipid sulfotransferase in human renal cancer cells. Int J Cancer 71:620–623
Yamachika T, Nakanishi H, Inada K, Kitoh K, Kato T, Irimura T, Tatematsu M (1997) Reciprocal control of colon-specific sulfomucin and sialosyl-Tn antigen expression in human colorectal neoplasia. Virchows Arch 431:25–30
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Japan
About this chapter
Cite this chapter
Honke, K. (2002). βGal 3-O-Sulfotransferase-1, -2, -3, and -4. In: Taniguchi, N., et al. Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67877-9_73
Download citation
DOI: https://doi.org/10.1007/978-4-431-67877-9_73
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-67996-7
Online ISBN: 978-4-431-67877-9
eBook Packages: Springer Book Archive