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Handbook of Glycosyltransferases and Related Genes pp 491–495Cite as

Heparan Sulfate/Heparin N-Deacetylase/ N-Sulfotransferase-2

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Abstract

Glucosaminyl N-deacetylase/N-sulfotransferase-2 (NDST-2) is a modification enzyme involved in heparin/heparan sulfate (HS) biosynthesis. This bifunctional enzyme catalyzes replacement of the acetyl group in GlcNAc with a sulfate group, which is the first modification step following polymerization of the (GlcNAc-GlcA)n precursor of heparin/HS. It is a key step during biosynthesis, as subsequent modifications, including GlcA epimerization and O-sulfation at various positions occur only in the vicinity of N- sulfate groups. Four mammalian NDST isoforms have been identified. At present, the specific roles of the various isoforms involved in heparin/HS biosynthesis are not known. Single orthologs are present in Drosophila melanogaster and Caenorhabditis elogans.

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Authors and Affiliations

  1. Department of Medical Biochemistry and Microbiology, University of Uppsala, The BiomedicalCenter, Husargatan 3, Box 582, SE-751, 23 Uppsala, Sweden

    Lena Kjellén

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  1. Lena Kjellén
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Editors and Affiliations

  1. Department of Biochemistry, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Naoyuki Taniguchi M.D., Ph.D. (Professor) & Koichi Honke M.D., Ph.D. (Associate Professor) (Professor) &  (Associate Professor)

  2. Glycobiology Program, Cancer Research Institute, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Minoru Fukuda Ph.D. (Professor) (Professor)

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© 2002 Springer Japan

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Kjellén, L. (2002). Heparan Sulfate/Heparin N-Deacetylase/ N-Sulfotransferase-2. In: Taniguchi, N., et al. Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67877-9_71

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  • DOI: https://doi.org/10.1007/978-4-431-67877-9_71

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67996-7

  • Online ISBN: 978-4-431-67877-9

  • eBook Packages: Springer Book Archive

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