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Heparan Sulfate/Heparin N-Deacetylase/ N-Sulfotransferase-2

  • Lena Kjellén

Abstract

Glucosaminyl N-deacetylase/N-sulfotransferase-2 (NDST-2) is a modification enzyme involved in heparin/heparan sulfate (HS) biosynthesis. This bifunctional enzyme catalyzes replacement of the acetyl group in GlcNAc with a sulfate group, which is the first modification step following polymerization of the (GlcNAc-GlcA)n precursor of heparin/HS. It is a key step during biosynthesis, as subsequent modifications, including GlcA epimerization and O-sulfation at various positions occur only in the vicinity of N- sulfate groups. Four mammalian NDST isoforms have been identified. At present, the specific roles of the various isoforms involved in heparin/HS biosynthesis are not known. Single orthologs are present in Drosophila melanogaster and Caenorhabditis elogans.

Keywords

Mast Cell Heparan Sulfate Sulfate Group Phospho Sulfate Iduronic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Lena Kjellén
    • 1
  1. 1.Department of Medical Biochemistry and MicrobiologyUniversity of Uppsala, The BiomedicalCenter23 UppsalaSweden

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