Heparan Sulfate/Heparin N-Deacetylase/ N-Sulfotransferase-1
Heparan sulfate N-sulfotransferase-1 (NST-1) was first identified as a Golgi enzyme that catalyzes N-sulfation of the glucosamine moiety (GlcN) of the glycosaminogly- can chain of heparan sulfate (HS). This enzyme was later demonstrated to catalyze another reaction, the N-deacetylation of N-acetylghicosamine (GlcNAc), the step immediately preceding N-sulfation (Wei et al. 1993) (Fig. 1). This enzyme, known now as heparan sulfate N-deacetylase/N-surfotransferase-l (NDST-1), thus catalyzes two sequential reactions that are obligatory initiation steps in the modification of the HS glycosaminoglycan (Lindahl et al. 1998; Bernfield et al. 1999).
KeywordsHeparan Sulfate Pulmonary Hypoplasia Mastocytoma Cell Sulfotransferase Activity Cell Surface Heparan Sulfate Proteoglycan
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- Aikawa J, Esko JD (1999b) Molecular cloning and expression of the third and fourth members of the heparan sulfate/heparin N-deacetylase/N-sulfotransferase family. Glycoconj J 16:S40Google Scholar
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