Heparan Sulfate/Heparin N-Deacetylase/ N-Sulfotransferase-1
Heparan sulfate N-sulfotransferase-1 (NST-1) was first identified as a Golgi enzyme that catalyzes N-sulfation of the glucosamine moiety (GlcN) of the glycosaminogly- can chain of heparan sulfate (HS). This enzyme was later demonstrated to catalyze another reaction, the N-deacetylation of N-acetylghicosamine (GlcNAc), the step immediately preceding N-sulfation (Wei et al. 1993) (Fig. 1). This enzyme, known now as heparan sulfate N-deacetylase/N-surfotransferase-l (NDST-1), thus catalyzes two sequential reactions that are obligatory initiation steps in the modification of the HS glycosaminoglycan (Lindahl et al. 1998; Bernfield et al. 1999).
KeywordsHeparan Sulfate Pulmonary Hypoplasia Mastocytoma Cell Sulfotransferase Activity Cell Surface Heparan Sulfate Proteoglycan
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Unable to display preview. Download preview PDF.
- Aikawa J, Esko JD (1999b) Molecular cloning and expression of the third and fourth members of the heparan sulfate/heparin N-deacetylase/N-sulfotransferase family. Glycoconj J 16:S40Google Scholar
© Springer Japan 2002