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Heparan Sulfate 2-Sulfotransferase

  • Hiroko Habuchi
  • Koji Kimata

Abstract

Heparan sulfate proteoglycans (HSPGs) are ubiquitously present on cell surfaces and in extracellular matrices including basement membranes; they have divergent structures and functions. The heparan sulfate chains in HSPGs are known to interact with a variety of proteins, such as heparin-binding growth factors, extracellular matrix components, protease inhibitors, proteases, and lipoprotein lipase. These interactions are implicated not only in various dynamic cellular behaviors including cell proliferation, differentiation, adhesion, migration, and morphogenesis during development but also in physiological phenomena such as inflammation, blood coagulation, and tumor cell invasion and malignancy. Moreover, some pathogens (e.g., bacteria, parasites, viruses) are known to interact with the cell surface HSPGs on host cells; and the heparan sulfate chains in most cases are ligands for the coat proteins or cell surface proteins of pathogens.

Keywords

Heparan Sulfate Fibroblast Growth Factor Receptor Basic Fibroblast Growth Factor Renal Agenesis Heparan Sulfate Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Hiroko Habuchi
    • 1
  • Koji Kimata
    • 1
  1. 1.The Institute for Molecular Science of MedicineAichi Medical University, NagakuteAichiJapan

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