Heparan Sulfate 2-Sulfotransferase
Heparan sulfate proteoglycans (HSPGs) are ubiquitously present on cell surfaces and in extracellular matrices including basement membranes; they have divergent structures and functions. The heparan sulfate chains in HSPGs are known to interact with a variety of proteins, such as heparin-binding growth factors, extracellular matrix components, protease inhibitors, proteases, and lipoprotein lipase. These interactions are implicated not only in various dynamic cellular behaviors including cell proliferation, differentiation, adhesion, migration, and morphogenesis during development but also in physiological phenomena such as inflammation, blood coagulation, and tumor cell invasion and malignancy. Moreover, some pathogens (e.g., bacteria, parasites, viruses) are known to interact with the cell surface HSPGs on host cells; and the heparan sulfate chains in most cases are ligands for the coat proteins or cell surface proteins of pathogens.
KeywordsHeparan Sulfate Fibroblast Growth Factor Receptor Basic Fibroblast Growth Factor Renal Agenesis Heparan Sulfate Chain
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