Chondroitin 4-sulfate, which contains a sulfate group on position 4 of GalNAc residues, is a major component of cartilage proteoglycan (aggrecan). Chondroitin 4- sulfate is also implicated in the celluar interaction with Plasmodium falciparum- infected erythrocytes (Rogerson et al. 1995; Fried and Duffy 1996). Chondroitin 4-sulfotransferase (C4ST) catalyzes the transfer of sulfate to position 4 of GalNAc residues of chondroitin and is involved in the biosynthesis of chondroitin 4-sulfate. cDNAs encoding mouse C4ST and human C4ST-1 and C4ST-2 have been cloned (Hiraoka et al. 2000; Yamauchi et al. 2000) mouse C4ST-1 is considered to be the mouse counterpart of human C4ST-1. All of the enzymes encoded by these cDNAs add 4-O- sulfate on dermatan sulfate using an in vitro assay. It remains to be studied whether C4ST is also involved in in vivo biosynthesis of dermatan sulfate.
KeywordsDermatan Sulfate Infected Erythrocyte Cartilage Proteoglycan Phospho Sulfate GalNAc Residue
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