Corneal N-Acetylglucosamine 6-O-Sulfotransferase
Keratan sulfate glycosaminoglycan, which is found mainly in the cornea and in cartilage tissues, consists of a linear poly-N-acetyllactosamine chain that carries sulfate residues on its C-6 position of GlcNAc and Gal. So far two human sulfotransferases have been reported to transfer sulfate on poly-N-acetyllactosamine and to produce keratan sulfate. One of the sulfotransferases, corneal GlcNAc 6-O-sulfotransferase (C- GlcNAc6ST, GlcNAc6ST-5) is known to be involved in a hereditary eye disease, macular corneal dystrophy. This enzyme has an important role in processing keratan sulfate.
KeywordsCarbohydrate Chain Human Cornea Sulfate Lead Sulfotransferase Activity Macular Corneal Dystrophy
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