Chondroitin 6-Sulfotransferase

  • Osami Habuchi


Chondroitin sulfate chains are composed of GlcAβ1-3GalNAcβ1-4 repeating unit with sulfate groups on GalNAc residues or on both GalNAc and GlcA residues. Sulfate groups attached to the backbone sugar chain produce various chondroitin sulfate isomers. Chondroitin 6-sulfate, which contains sulfate at position 6 of the GalNAc residue, is one of the major components of aggrecan and is thought to be involved in the formation and maintenance of cartilage. Chondroitin 6-sulfate is also contained in other various proteoglycans, such as phosphacan/PTPζ, and is proposed to be involved in neuronal cell interactions with growth factors pleiotrophin and midkine (Maeda et al. 1996, 1999). Chondroitin 6-sulfotransferase (C6ST) catalyzes the transfer of sulfate to position 6 of GalNAc residues of chondroitin. C6ST also sulfates the 6-position of Gal residue of keratan sulfate and sialyl N-acetyllactosamine oligosaccharides.


Chondroitin Sulfate Keratan Sulfate Chondroitin Sulfate Chain GalNAc Residue GlcA Residue 
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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Osami Habuchi
    • 1
  1. 1.Department of Life ScienceAichi University of Education, Igaya-cho, KariyaAichiJapan

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