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Chondroitin 6-Sulfotransferase

  • Osami Habuchi

Abstract

Chondroitin sulfate chains are composed of GlcAβ1-3GalNAcβ1-4 repeating unit with sulfate groups on GalNAc residues or on both GalNAc and GlcA residues. Sulfate groups attached to the backbone sugar chain produce various chondroitin sulfate isomers. Chondroitin 6-sulfate, which contains sulfate at position 6 of the GalNAc residue, is one of the major components of aggrecan and is thought to be involved in the formation and maintenance of cartilage. Chondroitin 6-sulfate is also contained in other various proteoglycans, such as phosphacan/PTPζ, and is proposed to be involved in neuronal cell interactions with growth factors pleiotrophin and midkine (Maeda et al. 1996, 1999). Chondroitin 6-sulfotransferase (C6ST) catalyzes the transfer of sulfate to position 6 of GalNAc residues of chondroitin. C6ST also sulfates the 6-position of Gal residue of keratan sulfate and sialyl N-acetyllactosamine oligosaccharides.

Keywords

Chondroitin Sulfate Keratan Sulfate Chondroitin Sulfate Chain GalNAc Residue GlcA Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Osami Habuchi
    • 1
  1. 1.Department of Life ScienceAichi University of Education, Igaya-cho, KariyaAichiJapan

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