Chondroitin sulfate chains are composed of GlcAβ1-3GalNAcβ1-4 repeating unit with sulfate groups on GalNAc residues or on both GalNAc and GlcA residues. Sulfate groups attached to the backbone sugar chain produce various chondroitin sulfate isomers. Chondroitin 6-sulfate, which contains sulfate at position 6 of the GalNAc residue, is one of the major components of aggrecan and is thought to be involved in the formation and maintenance of cartilage. Chondroitin 6-sulfate is also contained in other various proteoglycans, such as phosphacan/PTPζ, and is proposed to be involved in neuronal cell interactions with growth factors pleiotrophin and midkine (Maeda et al. 1996, 1999). Chondroitin 6-sulfotransferase (C6ST) catalyzes the transfer of sulfate to position 6 of GalNAc residues of chondroitin. C6ST also sulfates the 6-position of Gal residue of keratan sulfate and sialyl N-acetyllactosamine oligosaccharides.
KeywordsChondroitin Sulfate Keratan Sulfate Chondroitin Sulfate Chain GalNAc Residue GlcA Residue
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- Uchimura K, Kadomatsu K, Muramatsu H, Ishihama H, Nakamura E, Kurosawa N, Habuchi O, Muramatsu T (1999) Targeted disruption of the mouse chondroitin 6-sulfotransferase gene. Abstracts of International Conference on Molecular Interactions of Proteoglycans, Shonan Village Center, Kanagawa, JapanGoogle Scholar