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β3-Galactosyltransferase-IV (GM1 Synthase)

  • Koichi Furukawa

Abstract

β3-Galactosyltransferase-IV (β3GalT-IV) is an enzyme which catalyzes the conversion of GM2, GD2, and asialo-GM2 to GM1, GD1b, and asialo-GM1 (Gal), respectively (Miyazaki et al. 1997). This step is critical for the synthesis of major complex gangliosides such as GM1, GD1a, GDlb, GT1b, and GQ1b, which are enriched in the nervous system of vertebrates. Therefore, all major complex gangliosides are synthesized via the direct products of this enzyme. The cDNAs of β3GalT-IV were isolated by a eukaryocyte expression cloning system in 1997 (Miyazaki et al. 1997). This enzyme utilizes only glycolipid acceptors, not glycoproteins, and no other enzymes (genes) catalyzing similar functions have been detected to date. In the mouse genome (Mus musculus major histocompatibility locus class II region), a highly homologous gene as an orthologue to rat β3-galactosyltransferase-IV was reported by Rowen et al. (see AF100956, AF110520).

Keywords

Cholera Toxin Neural Retina Complex Ganglioside High mRNA Expression Level Substrate Specificity Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Koichi Furukawa
    • 1
  1. 1.Department of Biochemistry IINagoya University School of MedicineShowa-kuJapan

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