• Mari Kono
  • Shuichi Tsuji


ST8Sia-V was the fifth molecule cloned as an α2-8-sialyltransferase. This enzyme exists as three isoforms as ST8Sia-V-L, -M, -S in mice. The predicted amino acid sequences of mouse ST8Sia-V-L, -M, -S are 412, 376, and 345, respectively, all of which exhibit a type II transmembrane topology, consisting of an NH2 terminal cytoplasmic tail, a transmembrane domain, a proline-rich stem region, and a large COOH- terminal active domain. The nucleotide sequences of the three isoforms are identical to each other except in the putative stem region (Kono et al. 1996).


Transmembrane Topology Ganglioside Biosynthesis Acceptor Substrate Specificity Mouse Brain cDNA Library Oligonucleotide Prime Base 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Mari Kono
    • 1
  • Shuichi Tsuji
    • 2
  1. 1.Genetics of Development and Disease BranchNational Institutes of HealthBethesdaUSA
  2. 2.Department of Chemistry, Faculty of ScienceOchanomizu University, OtsukaBunkyo-kuJapan

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