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Handbook of Glycosyltransferases and Related Genes pp 340–346Cite as

ST8Sia-IV (PST-1)

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Abstract

ST8Sia-IV belongs to a member of the sialyltransferase family and forms polysialic acid (PSA) mainly attached to neural cell adhesion molecules (N-CAM). PSA is a glycan composed of a linear homopolymer of α2,8-linked sialic acid, which contains as many as 55 sialic acid residues per chain (Livingston et al. 1988). The expression of PSA in the brain dramatically decreases during development (Fig. 1), suggesting that this unique glycan is implicated in various neural events such as cell migration, neurite outgrowth, and neural plasticity by modulating the adhesive property of N- CAM (for reviews, see: Fryer and Hockfield 1996; Rutishauser and Landmesser 1996; Walsh and Doherty 1996; Kiss and Rougon 1997; Nakayama et al. 1998). In addition, PSA is also involved in the pathogenesis or metastatic potential of certain tumors such as neuroblastoma, small and nonsmall cell lung cancer, Wilm’s tumor, and pancreatic cancer (Roth et al. 1988; Scheidegger et al. 1994; Hildebrandt et al. 1998; Kameda et al. 1999; Tanaka et al. 2000; Tanaka et al. 2001).

Developmental expression of PSA in mouse brain. PSA is abundantly expressed in the midbrain at embryonic day 12 (a), whereas its expression level is significantly decreased in the adult brain, except for the hippocampus (b) and olfactory bulb. Immunostaining with anti-PSA antibody, 12F8; bar = 500 μm

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Authors and Affiliations

  1. Institutes of Organ Transplants, Reconstructive Medicine and Tissue Engineering, Shinshu University Graduate School of Medicine, and Central Clinical Laboratories, Shinshu University Hospital, Asahi 3-1-1, Matsumoto, 390-8621, Japan

    Jun Nakayama

  2. Glycobiology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Kiyohiko Angata, Misa Suzuki & Minoru Fukuda

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  1. Jun Nakayama
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  2. Kiyohiko Angata
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  3. Misa Suzuki
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  4. Minoru Fukuda
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Editors and Affiliations

  1. Department of Biochemistry, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Naoyuki Taniguchi M.D., Ph.D. (Professor) & Koichi Honke M.D., Ph.D. (Associate Professor) (Professor) &  (Associate Professor)

  2. Glycobiology Program, Cancer Research Institute, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Minoru Fukuda Ph.D. (Professor) (Professor)

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© 2002 Springer Japan

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Nakayama, J., Angata, K., Suzuki, M., Fukuda, M. (2002). ST8Sia-IV (PST-1). In: Taniguchi, N., et al. Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67877-9_48

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  • DOI: https://doi.org/10.1007/978-4-431-67877-9_48

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67996-7

  • Online ISBN: 978-4-431-67877-9

  • eBook Packages: Springer Book Archive

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