ST8Sia-IV (PST-1)

  • Jun Nakayama
  • Kiyohiko Angata
  • Misa Suzuki
  • Minoru Fukuda


ST8Sia-IV belongs to a member of the sialyltransferase family and forms polysialic acid (PSA) mainly attached to neural cell adhesion molecules (N-CAM). PSA is a glycan composed of a linear homopolymer of α2,8-linked sialic acid, which contains as many as 55 sialic acid residues per chain (Livingston et al. 1988). The expression of PSA in the brain dramatically decreases during development (Fig. 1), suggesting that this unique glycan is implicated in various neural events such as cell migration, neurite outgrowth, and neural plasticity by modulating the adhesive property of N- CAM (for reviews, see: Fryer and Hockfield 1996; Rutishauser and Landmesser 1996; Walsh and Doherty 1996; Kiss and Rougon 1997; Nakayama et al. 1998). In addition, PSA is also involved in the pathogenesis or metastatic potential of certain tumors such as neuroblastoma, small and nonsmall cell lung cancer, Wilm’s tumor, and pancreatic cancer (Roth et al. 1988; Scheidegger et al. 1994; Hildebrandt et al. 1998; Kameda et al. 1999; Tanaka et al. 2000; Tanaka et al. 2001).
Fig. 1

Developmental expression of PSA in mouse brain. PSA is abundantly expressed in the midbrain at embryonic day 12 (a), whereas its expression level is significantly decreased in the adult brain, except for the hippocampus (b) and olfactory bulb. Immunostaining with anti-PSA antibody, 12F8; bar = 500 μm


Sialic Acid Olfactory Bulb Neurite Outgrowth Neural Cell Adhesion Molecule Polysialic Acid 
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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Jun Nakayama
    • 1
  • Kiyohiko Angata
    • 2
  • Misa Suzuki
    • 2
  • Minoru Fukuda
    • 2
  1. 1.Institutes of Organ Transplants, Reconstructive Medicine and Tissue Engineering, Shinshu University Graduate School of Medicine, and Central Clinical LaboratoriesShinshu University HospitalMatsumotoJapan
  2. 2.Glycobiology ProgramBurnham InstituteLa JollaUSA

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