• Yukiko Yoshida
  • Shuichi Tsuji


The predicted amino acid sequence of mouse ST8Sia-III (mST8Sia-III) shows a protein of 380 amino acids with a type II transmembrane topology, as has been found for all sialyltransferases cloned to date. The sequence shows 16.9, 26.1, 26.2, and 17.2% identity with those of mST8Sia-I, -II, -IV, and -V, respectively. The mST8Sia-III transfers sialic acids toward Siaα2-3Galβ1-4GlcNAc sequences on both N-linked oli- gosaccharides of glycoproteins and α2-3sialylated glycosphingolipids, such as α2,3-sialylparagloboside and GM3. The mST8Sia-III gene was expressed only in brain and testis, and was well regulated during brain development.


Sialic Acid Polysialic Acid Transmembrane Topology mRNA AF004668 Acceptor Substrate Specificity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Yukiko Yoshida
    • 1
  • Shuichi Tsuji
    • 2
  1. 1.Department of Tumor ImmunologyTokyo Metropolitan Institute of Medical ScienceTokyoJapan
  2. 2.Department of Chemistry, Faculty of ScienceOchanomizu University, Otsuka, Bunkyo-kuTokyoJapan

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