ST8Sia-I (GD3 Synthase, SAT-II)

  • Yutaka Sanai


GD3 synthase and its biosynthetic products, b-series gangliosides, have been suggested to have significant roles in development because of their unique expression patterns during neuronal differentiation. In extraneural tissues, GD3 is implicated in cell attachment, cell-to-cell interactions during embryogenesis, and signal transduction in the glycolipid-enriched microdomain. These observations suggest that GD3 may play an important role not only in brain development, but also in extraneural tissues. GD3 synthase (CMP-N-acetylneuraminate: GM3 α2,8-sialyltransferase) is a key enzyme of ganglioside synthesis that, in concert with GM2 synthase, regulates the ratio of a- and b-pathway gangliosides. The ganglioside composition of cells and tissues thus reflects the relative expression of these two biosynthetic glycosyltrans- ferases. GD3 synthase is characteristically expressed in the early developmental stage of brain tissues.


Extraneural Tissue Ganglioside Composition Human Promyelocytic Leukemia Cell Line Embryonic Chicken Brain Ganglioside Synthesis 
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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Yutaka Sanai
    • 1
  1. 1.Department of Biochemical Cell ResearchTokyo Metropolitan Institute of Medical ScienceTokyoJapan

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