ST8Sia-I (GD3 Synthase, SAT-II)
GD3 synthase and its biosynthetic products, b-series gangliosides, have been suggested to have significant roles in development because of their unique expression patterns during neuronal differentiation. In extraneural tissues, GD3 is implicated in cell attachment, cell-to-cell interactions during embryogenesis, and signal transduction in the glycolipid-enriched microdomain. These observations suggest that GD3 may play an important role not only in brain development, but also in extraneural tissues. GD3 synthase (CMP-N-acetylneuraminate: GM3 α2,8-sialyltransferase) is a key enzyme of ganglioside synthesis that, in concert with GM2 synthase, regulates the ratio of a- and b-pathway gangliosides. The ganglioside composition of cells and tissues thus reflects the relative expression of these two biosynthetic glycosyltrans- ferases. GD3 synthase is characteristically expressed in the early developmental stage of brain tissues.
KeywordsExtraneural Tissue Ganglioside Composition Human Promyelocytic Leukemia Cell Line Embryonic Chicken Brain Ganglioside Synthesis
Unable to display preview. Download preview PDF.
- Okada M, Furukawa K, Yamashiro S, Yamada Y, Haraguchi M, Horibe K, Kato K, Tsuji Y (1996) High expression of ganglioside α-2,8-sialyltransferase (GD3 synthase) gene in adult T-cell leukemia cells unrelated to the gene expression of human T-lymphotropic virus type ICancer Res 56:2844–2848Google Scholar
- Trinchera M, Pirovano B, Ghidoni R (1990) Sub-Golgi distribution in rat liver of CMP-NeuAc GM3-and CMP-NeuAc:GTlb α-2-8sialyltransferases and comparison with the distribution of the other glycosyltransferase activities involved in ganglioside biosynthesis. J Biol Chem 265:18242–18247PubMedGoogle Scholar