• Nobuyuki Kurosawa
  • Shuichi Tsuji


ST6GalNAc-II is a CMP-sialic acid: N-acetylgalactosaminide α2-6-sialyltransferase (GalNAc α2-6-sialyltransferase), and the second member of the ST6GalNAc subfamily that exhibits activity toward GalNAc-O-Ser/Thr, Galβ1,3GalNAc-O-Ser/Thr, and NeuAcα2,3Galβ1,3GalNAc-O-Ser/Thr (Kurosawa et al. 1994, 1996; Kono et al. 2000). Like other sialyltransferases, ST6GalNAc-II exhibits type II membrane protein topology and has characteristic motifs for sialyltransferases called sialylmotifs L, S, and VS. ST6GalNAc-II also has a Kurosawa motif (Cys-Xaa75–82-Cys-Xaa-Cys-Ala-Xaa- Vα1-Xaa150-in160-Cys; Xaa denotes any amino acid residue) as seen in the ST3Gal family and two members of the ST6GalNAc family (Kurosawa et al. 1996; Tsuji 1999). Mouse ST6GalNAc-II cDNA encodes a protein of 373 amino acids, showing low identity to chick ST6GalNAc-II (57%) and -I (38%), and mouse ST6GalNAc-I (41%), -III (20%), -IV (22%), and -V (20%).


Mammary Gland Acceptor Substrate Fusion Enzyme Amino Acid Codon Similar Substrate Specificity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Nobuyuki Kurosawa
    • 1
  • Shuichi Tsuji
    • 2
  1. 1.Department of Materials and Biosystem Engineering, Faculty of EngineeringToyama UniversityToyamaJapan
  2. 2.Department of Chemistry, Faculty of ScienceOchanomizu University, Otsuka, Bunkyo-kuTokyoJapan

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