ST3Gal-V (GM3 Synthase, SAT-I)
ST3Gal-V (GM3 synthase) belongs to the sialyltransferase family, and is a unique enzyme among all sialyltransferases so far identified since it is specifically involved in ganglioside GM3 formation. Since GM3 is a common precursor of almost all gangliosides (especially ganglio-series gangliosides), GM3 synthase plays an important role in the biosynthesis of more complex gangliosides, and primarily regulates the amount of GM3. As is found in all members of the sialyltransferase family, the cloned ST3Gal-Vs from different animal origins encode type II membrane proteins with two conserved regions, i.e., sialylmotifs L and S, although an invariant aspartic acid residue in sialylmotif Ls of all other sialyltransferases is characteristically replaced by histidine residue (Ishii et al. 1998; Kono et al. 1998; Fukumoto et al. 1999).
KeywordsComplex Ganglioside National Cancer Center Research Institute Ganglioside Biosynthesis Acetylneuraminic Acid NFS60 Cell
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