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α3-Fucosyltransferase-VI (FUT6)

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Book cover Handbook of Glycosyltransferases and Related Genes

Abstract

Fuc-TVI (FUT6) was cloned as a fourth member of the human α1→3/4 fucosyltransferase gene family by Weston et al. in 1992. The enzyme shared 85% and 89% amino acid sequence identity with previously cloned Fuc-TIII (FUT3) and Fuc-TV (FUT5), respectively, and the FUT6 gene encoding the enzyme was shown to be located on chromosome 19, where the genes for FUT3 and FUT5 were known to be located. FUT6 could synthesize Lewis X and sialyl Lewis X, but not Lewis A or sialyl Lewis A. The enzyme turned out to be a “plasma-type” fucosyltransferase, and is known to synthesize the sialyl Lewis X determinant carried by plasma proteins and epithelial cancer cells.

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Authors and Affiliations

  1. Department of Molecular Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden. Chikusaku, Nagoya, 464-8681, Japan

    Reiji Kannagi

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  1. Reiji Kannagi
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Editors and Affiliations

  1. Department of Biochemistry, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Naoyuki Taniguchi M.D., Ph.D. (Professor) & Koichi Honke M.D., Ph.D. (Associate Professor) (Professor) &  (Associate Professor)

  2. Glycobiology Program, Cancer Research Institute, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Minoru Fukuda Ph.D. (Professor) (Professor)

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© 2002 Springer Japan

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Kannagi, R. (2002). α3-Fucosyltransferase-VI (FUT6). In: Taniguchi, N., et al. Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67877-9_31

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  • DOI: https://doi.org/10.1007/978-4-431-67877-9_31

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67996-7

  • Online ISBN: 978-4-431-67877-9

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