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α3-Fucosyltransferase-VI (FUT6)

  • Reiji Kannagi

Abstract

Fuc-TVI (FUT6) was cloned as a fourth member of the human α1→3/4 fucosyltransferase gene family by Weston et al. in 1992. The enzyme shared 85% and 89% amino acid sequence identity with previously cloned Fuc-TIII (FUT3) and Fuc-TV (FUT5), respectively, and the FUT6 gene encoding the enzyme was shown to be located on chromosome 19, where the genes for FUT3 and FUT5 were known to be located. FUT6 could synthesize Lewis X and sialyl Lewis X, but not Lewis A or sialyl Lewis A. The enzyme turned out to be a “plasma-type” fucosyltransferase, and is known to synthesize the sialyl Lewis X determinant carried by plasma proteins and epithelial cancer cells.

Keywords

Epithelial Cancer Cell Sialyl Lewisx Altered mRNA Expression Fucosyltransferase Activity Fucosyltransferase Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Reiji Kannagi
    • 1
  1. 1.Department of Molecular PathologyAichi Cancer Center Research InstituteNagoyaJapan

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