In 1992, Weston et al. isolated a human α3 fucosyltransferase gene homologous to, but distinct from, previously reported genes for two fucosyltransferases, Fuc-TIII (FUT3) and Fuc-TIV (FUT4), and named it Fuc-TV (FUT5). FUT5 shared 91% amino acid sequence identity with FUT3, and the FUT5 gene encoding the enzyme was located on chromosome 19, which is similar to that for FUT3. The gene is only sparsely expressed in cells and tissues, and its physiological function remains largely unknown, while the enzymatic characteristics of the recombinant enzyme have been studied extensively.
KeywordsAcceptor Substrate Full Enzyme Activity Fucosyltransferase Gene Established Tumoral Cell Line Human Malignant Cell Line
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