α3-Fucosyltransferase-IV (FUT4)

  • Hisashi Narimatsu


α3-Fucosyltransferase-IV (Fuc-TIV, FUT4) was cloned independently by two groups at almost the same time (Goelz et al. 1990; Lowe et al. 1991). It was first cloned as an α1,3-fucosyltransferase determining the expression of the ligand for the endotheliα1leukocyte adhesion molecule-1 (ELAM-1) by Goelz et al., and named ELAM-1 ligand fucosyltransferase (ELFT). Lowe et al. cloned it by cross-hybridization with a probe of FUT3 cDNA. However, the terms ELAM-1 and ELFT are not used at the present time. They have been renamed E-selectin and α3-fucosyltransferase-IV(Fuc-TIV, FUT4), respectively. The Fut4 gene is one of three active Fut genes, Fut4, 7, and 9, in rodents, and have been cloned from several species, i.e., mouse (Gersten et al. 1995, D63380), rat (U58860), and chicken (U73678). FUT4 is ubiquitously expressed in many tissues (Gersten et al. 1995; Kaneko et al. 1999). The chromosomal localization of human FUT4 and mouse Fut4 genes have been mapped on human chromosome 11q22-q23 and mouse choromosome 9, respectively (Gersten et al. 1995).


Myeloid Cell GlcNAc Residue Namalwa Cell Differential Site Deficient Neutrophil 
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© Springer Japan 2002

Authors and Affiliations

  • Hisashi Narimatsu
    • 1
  1. 1.Laboratory of Gene Function Analysis, Institute of Molecular and Cell Biology (IMCB)National Institute of Advanced Industrial Science and Technology (AIST)IbarakiJapan

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