α3/4-Fucosyltransferase (FUT3, Lewis enzyme)
α3/4-Fucosyltransferase was cloned for the first time among members of the α3- fucosyltransferases (Kukowska Latallo et al. 1990), and named Fuc-TIII by J. Lowe et al. or FUT3 by Oriol et al. Later, FUT3 (Fuc-TIII) was demonstrated to be the Lewis enzyme that determines the expression of Lewis histoblood group antigen, i.e., Lewis a (Lea) and Lewis b (Leb) (Mollicone et al. 1994; Nishihara et al. 1994). FUT3 catalyzes a transfer of Fuc from GDP-Fuc to the GlcNAc residue of type-2 chain, Galβ1-4GlcNAc, with an α1,3-linkage, or to the GlcNAc residue of type-1 chain, Galβ1-3GlcNAc, with an α1,4-linkage. The biosynthetic pathways of Lewis antigen epitopes in relation to ABH antigens are summarized in Fig. 1.
KeywordsGlcNAc Residue Lewis Antigen PUT3 Allele Lewis Blood Group Sialyl Lewisx
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