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α3/4-Fucosyltransferase (FUT3, Lewis enzyme)

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Handbook of Glycosyltransferases and Related Genes

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Abstract

α3/4-Fucosyltransferase was cloned for the first time among members of the α3- fucosyltransferases (Kukowska Latallo et al. 1990), and named Fuc-TIII by J. Lowe et al. or FUT3 by Oriol et al. Later, FUT3 (Fuc-TIII) was demonstrated to be the Lewis enzyme that determines the expression of Lewis histoblood group antigen, i.e., Lewis a (Lea) and Lewis b (Leb) (Mollicone et al. 1994; Nishihara et al. 1994). FUT3 catalyzes a transfer of Fuc from GDP-Fuc to the GlcNAc residue of type-2 chain, Galβ1-4GlcNAc, with an α1,3-linkage, or to the GlcNAc residue of type-1 chain, Galβ1-3GlcNAc, with an α1,4-linkage. The biosynthetic pathways of Lewis antigen epitopes in relation to ABH antigens are summarized in Fig. 1.

Biosynthetic pathways of type-1 to and type-2 Lewis antigens in correlation with the synthesis of ABO antigens. Lewis antigens with a type-1 chain are on the left, and those with a type-2 chain are on the right

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Authors and Affiliations

  1. Laboratory of Gene Function Analysis, Institute of Molecular and Cell Biology (IMCB), National Institute of Advanced Industrial Science and Technology (AIST), Central-2, 1-1-1 Umezono, Tsukuba, Ibaraki, 305-8568, Japan

    Hisashi Narimatsu

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  1. Hisashi Narimatsu
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Editors and Affiliations

  1. Department of Biochemistry, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Naoyuki Taniguchi M.D., Ph.D. (Professor) & Koichi Honke M.D., Ph.D. (Associate Professor) (Professor) &  (Associate Professor)

  2. Glycobiology Program, Cancer Research Institute, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Minoru Fukuda Ph.D. (Professor) (Professor)

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© 2002 Springer Japan

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Narimatsu, H. (2002). α3/4-Fucosyltransferase (FUT3, Lewis enzyme). In: Taniguchi, N., et al. Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67877-9_28

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  • DOI: https://doi.org/10.1007/978-4-431-67877-9_28

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67996-7

  • Online ISBN: 978-4-431-67877-9

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