α3/4-Fucosyltransferase (FUT3, Lewis enzyme)

  • Hisashi Narimatsu


α3/4-Fucosyltransferase was cloned for the first time among members of the α3- fucosyltransferases (Kukowska Latallo et al. 1990), and named Fuc-TIII by J. Lowe et al. or FUT3 by Oriol et al. Later, FUT3 (Fuc-TIII) was demonstrated to be the Lewis enzyme that determines the expression of Lewis histoblood group antigen, i.e., Lewis a (Lea) and Lewis b (Leb) (Mollicone et al. 1994; Nishihara et al. 1994). FUT3 catalyzes a transfer of Fuc from GDP-Fuc to the GlcNAc residue of type-2 chain, Galβ1-4GlcNAc, with an α1,3-linkage, or to the GlcNAc residue of type-1 chain, Galβ1-3GlcNAc, with an α1,4-linkage. The biosynthetic pathways of Lewis antigen epitopes in relation to ABH antigens are summarized in Fig. 1.
Fig. 1

Biosynthetic pathways of type-1 to and type-2 Lewis antigens in correlation with the synthesis of ABO antigens. Lewis antigens with a type-1 chain are on the left, and those with a type-2 chain are on the right


GlcNAc Residue Lewis Antigen PUT3 Allele Lewis Blood Group Sialyl Lewisx 
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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Hisashi Narimatsu
    • 1
  1. 1.Laboratory of Gene Function Analysis, Institute of Molecular and Cell Biology (IMCB)National Institute of Advanced Industrial Science and Technology (AIST)IbarakiJapan

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