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α3/4-Fucosyltransferase (FUT3, Lewis enzyme)

  • Hisashi Narimatsu

Abstract

α3/4-Fucosyltransferase was cloned for the first time among members of the α3- fucosyltransferases (Kukowska Latallo et al. 1990), and named Fuc-TIII by J. Lowe et al. or FUT3 by Oriol et al. Later, FUT3 (Fuc-TIII) was demonstrated to be the Lewis enzyme that determines the expression of Lewis histoblood group antigen, i.e., Lewis a (Lea) and Lewis b (Leb) (Mollicone et al. 1994; Nishihara et al. 1994). FUT3 catalyzes a transfer of Fuc from GDP-Fuc to the GlcNAc residue of type-2 chain, Galβ1-4GlcNAc, with an α1,3-linkage, or to the GlcNAc residue of type-1 chain, Galβ1-3GlcNAc, with an α1,4-linkage. The biosynthetic pathways of Lewis antigen epitopes in relation to ABH antigens are summarized in Fig. 1.
Fig. 1

Biosynthetic pathways of type-1 to and type-2 Lewis antigens in correlation with the synthesis of ABO antigens. Lewis antigens with a type-1 chain are on the left, and those with a type-2 chain are on the right

Keywords

GlcNAc Residue Lewis Antigen PUT3 Allele Lewis Blood Group Sialyl Lewisx 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Hisashi Narimatsu
    • 1
  1. 1.Laboratory of Gene Function Analysis, Institute of Molecular and Cell Biology (IMCB)National Institute of Advanced Industrial Science and Technology (AIST)IbarakiJapan

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