Forssman Glycolipid Synthase
More than 200 distinct glycosphingolipids have been reported from a wide variety of eukaryotic sources. Variability in glycosphingolipid structure occurs primarily in the carbohydrate moiety owing to differences in the number, sequence, or way of linkage between monosaccharide residues. Forssman glycolipid (GalNAcα1-3GalNAcβ1- 3Galα1-4Galβ1-4Glc-Cer, globopentaosylceramide) is a member of the globo series glycosphingolipid family, and is formed by the addition of GalNAc in α1,3-linkage to the terminal GalNAc residue of globoside (globotetraosylceramide). This reaction is catalyzed by Forssman glycolipid synthase (UDP-N-acetylgalactosamine:globoside α3-N-acetylgalactosaminyltransferase).
KeywordsLiquid Scintillation Technique mRNA AF163572 Eukaryotic Source Forssman Glycolipid Forssman Antigen
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