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Handbook of Glycosyltransferases and Related Genes pp 197–201Cite as

Forssman Glycolipid Synthase

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Abstract

More than 200 distinct glycosphingolipids have been reported from a wide variety of eukaryotic sources. Variability in glycosphingolipid structure occurs primarily in the carbohydrate moiety owing to differences in the number, sequence, or way of linkage between monosaccharide residues. Forssman glycolipid (GalNAcα1-3GalNAcβ1- 3Galα1-4Galβ1-4Glc-Cer, globopentaosylceramide) is a member of the globo series glycosphingolipid family, and is formed by the addition of GalNAc in α1,3-linkage to the terminal GalNAc residue of globoside (globotetraosylceramide). This reaction is catalyzed by Forssman glycolipid synthase (UDP-N-acetylgalactosamine:globoside α3-N-acetylgalactosaminyltransferase).

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Authors and Affiliations

  1. Department of Biochemistry, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Koichi Honke

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  1. Koichi Honke
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Editors and Affiliations

  1. Department of Biochemistry, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Naoyuki Taniguchi M.D., Ph.D. (Professor) & Koichi Honke M.D., Ph.D. (Associate Professor) (Professor) &  (Associate Professor)

  2. Glycobiology Program, Cancer Research Institute, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Minoru Fukuda Ph.D. (Professor) (Professor)

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© 2002 Springer Japan

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Honke, K. (2002). Forssman Glycolipid Synthase. In: Taniguchi, N., et al. Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67877-9_26

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  • DOI: https://doi.org/10.1007/978-4-431-67877-9_26

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67996-7

  • Online ISBN: 978-4-431-67877-9

  • eBook Packages: Springer Book Archive

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