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Core 2 β6-N- Acetylglucosaminyltransferase-II

  • Minoru Fukuda
  • Jiunn-Chern Yeh

Abstract

Core 2 β6-N-acetylglucosaminyltransferase-II (Core2GlcNAcT-II) is unique in having all of the core 2, core 4, and I branching activities (Yeh et al. 1999). Core2, core4, and I branching activities are related to each other, but distinguished by substrate acceptors (Fig. 1). Core2 and core4 branching enzymes add β1,6-N-acetylglucosamine to the GalNAc residue of either Galβ1-3GalNAcα1-Ser/Thr (for Core2GlcNAcT) or GlcNAcβ1-3GalNAcα1-Ser/Thr (for Core4GlcNAcT). I-branching enzyme adds β1,6- linked N-acetylglucosamine to Galβ1-4GlcNAcβ1-3Galβ1-4Glc(NAc)β1-R (for centrally acting cIGnT) or GlcNAcβ1-3Galβ1-4Glc(NAc)β1-R (for distally acting dIGnT), where the acceptor galactose is underlined.
Fig. 1

Acceptors and resultant products by three different β6-N-acetyllactosaminyltransferases. I β6-N-acetylglucosaminyltransferase (cIGnT), core2 β6-N-acetylglucosaminyltransferase (Core2GlcNAcT), and core4 β6-N-acetylglucosaminyltransferase (Core4GlcNAcT) are shown. For distally acting IGnT (dIGnT), GlcNAcβ1-3Galβ1-4 Glc(NAC)β-l-R is utilized as an acceptor

Keywords

Gastric Mucin Core3 Oligosaccharide GalNAc Residue Bovine Trachea Colonic Mucosal Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Minoru Fukuda
    • 1
  • Jiunn-Chern Yeh
    • 1
  1. 1.Glycobiology ProgramThe Burnham InstituteLa JollaUSA

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