Core 2 β6-N- Acetylglucosaminyltransferase-II

  • Minoru Fukuda
  • Jiunn-Chern Yeh


Core 2 β6-N-acetylglucosaminyltransferase-II (Core2GlcNAcT-II) is unique in having all of the core 2, core 4, and I branching activities (Yeh et al. 1999). Core2, core4, and I branching activities are related to each other, but distinguished by substrate acceptors (Fig. 1). Core2 and core4 branching enzymes add β1,6-N-acetylglucosamine to the GalNAc residue of either Galβ1-3GalNAcα1-Ser/Thr (for Core2GlcNAcT) or GlcNAcβ1-3GalNAcα1-Ser/Thr (for Core4GlcNAcT). I-branching enzyme adds β1,6- linked N-acetylglucosamine to Galβ1-4GlcNAcβ1-3Galβ1-4Glc(NAc)β1-R (for centrally acting cIGnT) or GlcNAcβ1-3Galβ1-4Glc(NAc)β1-R (for distally acting dIGnT), where the acceptor galactose is underlined.
Fig. 1

Acceptors and resultant products by three different β6-N-acetyllactosaminyltransferases. I β6-N-acetylglucosaminyltransferase (cIGnT), core2 β6-N-acetylglucosaminyltransferase (Core2GlcNAcT), and core4 β6-N-acetylglucosaminyltransferase (Core4GlcNAcT) are shown. For distally acting IGnT (dIGnT), GlcNAcβ1-3Galβ1-4 Glc(NAC)β-l-R is utilized as an acceptor


Gastric Mucin Core3 Oligosaccharide GalNAc Residue Bovine Trachea Colonic Mucosal Tissue 
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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Minoru Fukuda
    • 1
  • Jiunn-Chern Yeh
    • 1
  1. 1.Glycobiology ProgramThe Burnham InstituteLa JollaUSA

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