Core 2 β6-N- Acetylglucosaminyltransferase-I and -III
Core 2 β6-N-acetylglucosaminyltransferase (Core2GlcNAcT) is a glycosyltransferase that transfers GlcNAc from UDP-GlcNAc to αGalNAc residues in core 1, Galβ1- 3GalNAcα1-Ser/Thr with β1,6-linkage, forming Galβ1-3(GlcNAcβ1-6)GalNAcα1- Ser/Thr. The formation of the core 2 branch is usually followed by galactosylation by β4-galactosyltransferase-IV, a member of the β4-galactosyltransferase gene family (Ujita et al. 1998), resulting in the formation of N-acetyllactosamines in O-glycans. Such N-acetyllactosamines can be modified to form functional oligosaccharides such as sialyl Lewis X (Fig. 1).
KeywordsOligo Saccharide High Endothelial Venule Acute Myelogenous Leukemia Cell Selectin Ligand Human Thymic Epithelial Cell
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