Abstract
I-branching β6-N-acetylglucosaminyltransferase (IGnT) is a glycosyltransferase that catalyzes the transfer of GlcNAc from UDP-GlcNAc to β1,4-linked Gal residue in a linear poly-N-acetyllactosamine, ±Galβ1-4GlcNAcβ1-3Galβ1-4Glc(NAc)-R, forming ±Galβ1-4GlcNAcβ1-3(GlcNAcβ1-6)Galβ1-4Glc(NAc)-R. The formation of the I branch is usually followed by galactosylation with β4-galactosyltransferase I, resulting in the I antigen. The I-antigen can be further modified to express functional oligosaccharides, such as sialyl Lewis X (Fig. 1).
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Fukuda, M. (2002). β6-N-Acetylglucosaminyltransferase (IGnT). In: Taniguchi, N., et al. Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67877-9_17
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DOI: https://doi.org/10.1007/978-4-431-67877-9_17
Publisher Name: Springer, Tokyo
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