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β3-N-Acetylglucosaminyltransferase (iGnT)

  • Minoru Fukuda

Abstract

β3-N-Acetylglucosaminyrtransferase, i-extension enzyme (iGnT), is a glycosyltransferase that catalyzes the transfer of GlcNAc from UDP-GlcNAc to Gal in the Galβ1-4Glc(NAc) structure with β1,3-linkage. In N-glycans, the addition of β1,3- linked GlcNAc is usually followed by galactosylation by β1,4-galactosyltransferase I, the predominant member of the β1,4-galactosyltransferase gene family (Ujita et al. 1999, 2000). It has been shown that poly-N-acetyllactosamines can be efficiently modified to form functional oligosaccharides such as sialyl Lex.

Keywords

Chinese Hamster Ovary Cell Neisseria Meningitidis Recombinant Human Erythropoietin Baby Hamster Kidney Cell Myelogenous Leukemia Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Minoru Fukuda
    • 1
  1. 1.Glycobiology ProgramThe Burnham InstituteLa JollaUSA

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