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Barrett Carcinoma and Esophagus: Experience in Japan, an Area of Low Incidence

  • Yo Kato
  • Hisanobu Tomimatsu
  • Akio Yanagisawa
  • Toshiki Matsubara
  • Hiroshi Matsushita
Conference paper

Abstract

The incidence of adenocarcinoma among cases of esophageal carcinoma is more than 30% in the USA and several European countries, and recently the incidence of Barrett carcinoma (BCa) in U.S. Caucasians appears to be increasing together with that of cardiac adenocarcinoma [1]. However, according to our search for resected esophageal carcinomas registered with the Japanese Society for Esophageal Diseases OSED), the annual incidence of esophageal adenocarcioma, mainly BCa, among total esophageal carcinomas (mainly squamous cell carcinoma) was low and unchanged at 0.8%–2.2% over the 10 years from 1988 to 1997 [2,3]. Even if cases are limited to tumors of the abdominal esophagus where most esophageal adenocarcinomas develop, the incidence of adenocarcinoma is around 4%. In this chapter, we report the clinicopathologic characteristics of BCa patients and lesions we have treated in two institutions in Tokyo, Japan, an area with a low incidence of the tumor, and then discuss the histologic changes with high risk for adenocarcinoma development in Barrett esophagus (BE), i.e., the columnar-lined mucosa of the lower esophagus.

Keywords

Esophageal Carcinoma Intestinal Metaplasia Esophageal Disease Gastric Mucin Barrett Esophagus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Yo Kato
    • 1
  • Hisanobu Tomimatsu
    • 1
  • Akio Yanagisawa
    • 1
  • Toshiki Matsubara
    • 2
  • Hiroshi Matsushita
    • 3
  1. 1.Departments of PathologyJapanese Foundation for Cancer ResearchTokyoJapan
  2. 2.Departments of Digestive Surgery, Cancer InstituteJapanese Foundation for Cancer ResearchTokyoJapan
  3. 3.Department of PathologyToranomon HospitalTokyoJapan

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