Barrett Carcinoma and Esophagus: Experience in Japan, an Area of Low Incidence
The incidence of adenocarcinoma among cases of esophageal carcinoma is more than 30% in the USA and several European countries, and recently the incidence of Barrett carcinoma (BCa) in U.S. Caucasians appears to be increasing together with that of cardiac adenocarcinoma . However, according to our search for resected esophageal carcinomas registered with the Japanese Society for Esophageal Diseases OSED), the annual incidence of esophageal adenocarcioma, mainly BCa, among total esophageal carcinomas (mainly squamous cell carcinoma) was low and unchanged at 0.8%–2.2% over the 10 years from 1988 to 1997 [2,3]. Even if cases are limited to tumors of the abdominal esophagus where most esophageal adenocarcinomas develop, the incidence of adenocarcinoma is around 4%. In this chapter, we report the clinicopathologic characteristics of BCa patients and lesions we have treated in two institutions in Tokyo, Japan, an area with a low incidence of the tumor, and then discuss the histologic changes with high risk for adenocarcinoma development in Barrett esophagus (BE), i.e., the columnar-lined mucosa of the lower esophagus.
KeywordsEsophageal Carcinoma Intestinal Metaplasia Esophageal Disease Gastric Mucin Barrett Esophagus
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- 2.Japanese Society for Esophageal Diseases (1998) Annual statistics of Esophageal Cancer Registered (cases of 1988–1994) (in Japanese). Japanese Society for Esophageal DiseasesGoogle Scholar
- 3.Japanese Society for Esophageal Diseases (2001) Annual statistics of esophageal cancer registered (cases of 1995–1997) (in English). Japanese Society for Esophageal DiseasesGoogle Scholar
- 5.Koseki K, Takizawa T, Koike M, et al (1999) Subclassification of well-differentiated gastric cancer with reference of biological behavior and malignancy, gastric type vs intestinal type, and papillary carcinoma vs tubular carcinoma. Stomach Intestine 34: 507–512 (Japanese with English abstract)Google Scholar
- 6.Tomimatsu H, Kato Y, Sakai Y, et al (1999) Clinicopathological study on Bavretl’s cancer with analysis of its precancerous state. Gastroenterology 28:42–50 (Japanese)Google Scholar
- 7.Nishi T, Makuuchi H, Machimura T, et al (1995) A small adenocarcinoma arising in Barrett esophagus—A case report. Endoscopia Digestiva 7:557–563 (Japanese with English abstract)Google Scholar
- 10.Werner M, Flejou JF, Hainaut P, et al (2000) Adenocarcinoma of the esophagus. In: Hamilton SR and Aaltonen LA (eds) WHO classification. Tumours of the digestive systems. IARC, Lyon, pp 20–26Google Scholar