Telomerase Activity and p53 Protein Accumulation in Lugol-Stained and Lugol-Unstained Esophageal Squamous Epithelia

  • Yutaka Shimada
  • Maki Inai
  • Masato Kano
  • Takaki Sakurai
  • Tsutomu Chiba
  • Masayuki Imamura
Conference paper


Esophageal squamous cell carcinoma (ESC) is one of the most common cancers worldwide [1]. Its prognosis remains poor despite recent advances in both diagnosis and therapy. Moreover, multiple primary ESC is not uncommon [2,3]. These reports support the concept that the entire esophagus may be considered as a single area of carcinogenesis. The elucidation of the carcinogenesis of ESC may have a considerable effect on early diagnosis and therapy.


Esophageal Squamous Cell Carcinoma Precancerous Lesion Severe Dysplasia Esophageal Squamous Cell Carcinoma Tissue Mild Dysplasia 
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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Yutaka Shimada
    • 1
  • Maki Inai
    • 2
  • Masato Kano
    • 1
  • Takaki Sakurai
    • 3
  • Tsutomu Chiba
    • 2
  • Masayuki Imamura
    • 1
  1. 1.Departments of Surgery and Surgical Basic ScienceKyoto University, KawaharachoKyotoJapan
  2. 2.Departments of Gastroenterology and HepatologyKyoto University, KawaharachoKyotoJapan
  3. 3.Laboratory of Anatomic PathologyKyoto University, KawaharachoKyotoJapan

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