Molecular Biology of Adenocarcinoma Arising in Barrett’s Esophagus
The last several years have seen a rapid rise in the incidence of both Barrett’s esophagus and adenocarcinoma of the distal esophagus . Because most patients with these tumors present late owing to the lack of specific symptoms, the prognostic outlook for most is poor despite improvements in surgical treatment [2,3]. For this reason it has become apparent that successful therapeutic strategies must be based on early detection and treatment. This in turn has brought heightened interest to studying the carcinogenesis of these tumors, as a better understanding of their molecular biology could provide new diagnostic and therapeutic possibilities.
KeywordsComparative Genomic Hybridization Esophageal Adenocarcinoma Distal Esophagus Gastric Cardia Adenocarcinoma Chronic Reflux Esophagitis
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