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Superficial Esophageal Cancer: Adenocarcinoma Related to Barrett’s Metaplasia and Adenoid Cystic Carcinoma

  • Sauid Ishaq
  • Rebecca F. Harrison
  • Janusz A. Jankowski
Conference paper

Abstract

The rate of esophageal adenocarcinoma is rising, and the lesion has a poor prognosis mainly because of late presentation. Barrett’s metaplasia is a major risk factor in the epidemiology of esophageal adenocarcinoma, as individuals with Barrett’s metaplasia have an increased risk of adenocarcinoma of the lower esophagus [1]. Although highly curable at its early stages, esophageal cancer is usually fatal when it is more advanced [2, 3, 4]. Treatment and subsequent outcome are linked to its histology, accurate staging, and the site of the tumor [5,6].

Keywords

Esophageal Cancer Esophageal Carcinoma Intestinal Metaplasia Adenoid Cystic Carcinoma Esophageal Adenocarcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Stein HJ, Hoeft S, DeMeester TR (1993) Functional foregut abnormalities in Barrett’s esophagus. J Thorac Cardiovasc Surg 105:163–168Google Scholar
  2. 2.
    Steup WH, DeLeyn P, Deneffe I, et al (1996) Tumors of the esophagogastric junction: long-term survival in relation to the pattern of lymph node metastasis and a critical analysis of the accuracy or inaccuracy of pTNM classification. J Thorac Cardiovasc Surg 5:S17–S26Google Scholar
  3. 3.
    Clark GW, Peters JH, Ireland AP, et al (1994) Nodal metastasis and sites of recurrence after en bloc esophagectomy of adenocarcinoma. Ann Thorac Surg 58:646–654PubMedCrossRefGoogle Scholar
  4. 4.
    Hölscher AH, Bollschweiler E, Bumm R, et al (1995) Nodal metastasis and sites of recurrence after en bloc esophagectomy for adenocarcinoma of the esophagus. Surgery 118:845–855PubMedCrossRefGoogle Scholar
  5. 5.
    Lightdale CJ (1994) Staging of esophageal cancer. I. Endoscopic ultrasonography. Semin Oncol 21:438–446PubMedGoogle Scholar
  6. 6.
    Thompson WM, Halvorsen RA Jr (1994) Staging esophageal carcinoma II: CT and MRI. Semin Oncol 21:447–452PubMedGoogle Scholar
  7. 7.
    Macdonald CE, Wicks AC, Playford RJ (2000) Final results from 10 year cohort of patients undergoing surveillance for Barrett’s esophagitis: observational study. BMJ 321:1252–1255PubMedCrossRefGoogle Scholar
  8. 8.
    Morales TG, Sampliner RE (1999) Barrett’s esophagus: an update on screening, surveillance and treatment. Arch Intern Med 159:1411–1416PubMedCrossRefGoogle Scholar
  9. 9.
    Peters JH, Clark GW, Ireland AP, et al (1994) Outcome of adenocarcinoma arising in Barrett’s esophagus in endoscopically surveyed and non surveyed patients. J Thorac Cardiovasc Surg 108:813–821PubMedGoogle Scholar
  10. 10.
    Peters JH, Hoeft SF, Heimbucher J, et al (1994) Selection of patients for curative oe palliative resection of esophageal cancer based on preoperative endoscopic ultrasonography. Arch Surg 129:534–539PubMedCrossRefGoogle Scholar
  11. 11.
    Cameron AJ, Lomboy CT, Pera M, et al (1992) Adenocarcinoma of esophagogastric junction and Barrett’s esophagus. Gastroenterology 103:1241–1245PubMedGoogle Scholar
  12. 12.
    Jankowski J, Harrison R, Perry I, et al (2000) Barrett’s metaplasia. Lancet 356:2079–2085PubMedCrossRefGoogle Scholar
  13. 13.
    Hirota WK, Loughney TM, Lanzas DJ, Maydonovitch CL, Rholl V, Wong RKH (1999) Specialized intestinal metaplasia, dysplasia, and cancer of the esophagus and esophagogastric junction: prevalence and clinical data. Gastroenterology 116:277–285PubMedCrossRefGoogle Scholar
  14. 14.
    Prach AT, Mohiuddin MA, Geisinger KR, et al (1997) Increasing incidence of Barrett’s esophagus: education, enthusiasm, or epidemiology [letter]? Lancet 350:933PubMedCrossRefGoogle Scholar
  15. 15.
    Sanchez RC, Santalla PF, Retamero OMD (1995) Barrett esophagus: an epidemiological study in an area of Spain. Rev Esp Enferm Dig 87:353–355Google Scholar
  16. 16.
    Sarr MG, Hamilton SR, Marrone GC, et al (1985) Barrett’s esophagus: its prevalence and association with adenocarcinoma in patients with symptoms of gastroesophageal reflux. Am J Surg 149:187–193PubMedCrossRefGoogle Scholar
  17. 17.
    Skinner DB, Walther BC, Riddell RH (1983) Barrett’s esophagus: comparison of benign and malignant cases. Ann Surg 198:554–566PubMedCrossRefGoogle Scholar
  18. 18.
    Bonelli L (1993) Barrett’s esophagus: results of multicentric survey. G.O.S.P.E. (Gruppo Operativo per 10 studio delle Precancerosi Esofagee. Endoscopy 25:652–654PubMedCrossRefGoogle Scholar
  19. 19.
    Yeh C, Hsu C, Ho A, et al (1997) Erosive esophagitis and Barrett’s esophagus in Taiwan: a higher frequency than expected. Dig Dis Sci 42:702–706PubMedCrossRefGoogle Scholar
  20. 20.
    Chen PH (1997) Review: Barrett’s esophagus in Taiwan. J. Gastroenterol Hepatol 12:S19–S22CrossRefGoogle Scholar
  21. 21.
    Cameron AJ, Lomboy CT (1995) Adenocarcinoma of the esophagogastric junction and Barrett’s esophagus. Gastroenterology 103:1241–1245Google Scholar
  22. 22.
    Hamilton SR, Smith RR, Camerone JL (1988) Prevalence and characteristic of Barrett’s esophagus in patients with adenocarcinoma of esophagus or esophagogastric junction. Hum Pathol 19:942–948PubMedCrossRefGoogle Scholar
  23. 23.
    Blot WJ, Devesa SS, Kneller RW, et al (1993) Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA 265:1287–1289CrossRefGoogle Scholar
  24. 24.
    Haggit RC (1992) Adenocarcinoma in Barrett’s esophagus: a new epidemic [editorial]? Hum Pathol 23:475–476CrossRefGoogle Scholar
  25. 25.
    Pera M, Cameron AJ, Trastek VF, et al (1993) Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction. Gastroenterology 104:510–513PubMedGoogle Scholar
  26. 26.
    Jankowski J (2001) CRC cancer stats: Esophageal cancer. CRC Press, LondonGoogle Scholar
  27. 27.
    Poynton AR, Walsh TN, O’sullivan G, et al (1996) Carcinoma arising in familial barrett’s esophagus. Am J Gastroenterol 91:1855–1856PubMedGoogle Scholar
  28. 28.
    Fontolliet C, Ollyo JB, Brossard E (1994) Barrett’s esophagus may still progress. Gut 35(suppl):A27–A27CrossRefGoogle Scholar
  29. 29.
    Monnier P, Fontolliet C, Savary M, et al (1987) Barrett’s esophagus or columnar epithelium of lower esophagus. Ballieres Clin Gastroenterol 14:769–789CrossRefGoogle Scholar
  30. 30.
    Ollyo JB, Gonvers JJ, Froehlich F, et al (1990) Does Barrett’s esophagus regress after effective treatment of gastro-esophageal reflux? Schweiz Med Wochenschr 120:716–720PubMedGoogle Scholar
  31. 31.
    Sampliner RE, Practice Parameters Committee of the American College of Gastroenterology (1998) Practice guidelines on the diagnosis, surveillance, and therapy of Barrett’s esophagus. Am J Gastroenterol 93:1028–1032PubMedCrossRefGoogle Scholar
  32. 32.
    Cameron AJ (1998) Management of Barrett’s esophagus. Mayo Clin Proc 73:457–461PubMedCrossRefGoogle Scholar
  33. 33.
    Barrett MT, Sanchez CA, Prevo LJ, et al (1999) Evolution in neoplastic cell lineage in Barrett’s esophagus. Nat Genet 22:106–109PubMedCrossRefGoogle Scholar
  34. 34.
    Reid BJ, Blount PL, Rubin CE, et al (1992) Flow-cytometric and histological progression to malignancy in Barrett’s esophagus: prospective endoscopic surveillance of a cohort. Gastroenterology 102:1212–1219PubMedGoogle Scholar
  35. 35.
    Edwards MJ, Gable DR, Lentsch AB, et al (1996) The rationale for esophagectomy as the optimal therapy for Barrett’s esophagus with high-grade dysplasia. Ann Surg 223:585–589PubMedCrossRefGoogle Scholar
  36. 36.
    Morisaki Y, Yoshizumi Y, Hiroyasu S, et al (1996) Adenoid cystis carcinoma of the esophagus: report of a case and review of the Japanese literature. Surg Today 26:1006–1009PubMedCrossRefGoogle Scholar
  37. 37.
    Pera M, Trastek VF, Carpenter HA, et al (1992) Barrett’s esophagus with high grade dysplasia: an indication for esophagectomy: Ann Thorac Surg 54:199–204PubMedCrossRefGoogle Scholar
  38. 38.
    Spechler SJ, Goyal RK (1986) Barrett’s esophagus. N Engl J Med 315:362–371PubMedCrossRefGoogle Scholar
  39. 39.
    Spechler SJ, Robbins AH, Bloomfield Rubins H, et al (1984) Adenocarcinoma and Barrett’s esophagus: an overrated risk? Gastroenterology 87:927–933PubMedGoogle Scholar
  40. 40.
    Cameron AJ, Ott BJ, Payne WS (1985) The incidence in columnar-lined (Barrett’s) esophagus. N Engl J Med 313:857–859PubMedCrossRefGoogle Scholar
  41. 41.
    Williamson WA, Ellis FH Jr, Gibbs SP, et al (1991) Barrett’s esophagus: prevalence and incidence of adenocarcinoma. Arch Intern Med 151:2212–2216PubMedCrossRefGoogle Scholar
  42. 42.
    Drewitz DJ, Sampliner RE, Garewal HS (1997) The incidence of adenocarcinoma in Barrett’s esophagus: a prospective study of 170 patients followed 4.8 years. Am J Gastroenterol 92: 212–215PubMedGoogle Scholar
  43. 43.
    Shaheen NJ, Crosby MA, Bozymski EM, et al (2000) Is there publication bias in the reporting of cancer risk in Barrett’s esophagus? Gastroenterology 119:333–338PubMedCrossRefGoogle Scholar
  44. 44.
    Tuyns AJ (1992) Esophageal cancer in France and Switzerland: recent time trend. Eur J Cancer Prev 1:275–278PubMedCrossRefGoogle Scholar
  45. 45.
    Day NE, Munoz N, Ghadirian P (1982) Epidemiology of esophageal cancer: a review. In: Correa P, Haenszel W (eds) Epidemiology of cancer of the digestive tract. Martinus Nijhoff, The Hague, pp 21–57CrossRefGoogle Scholar
  46. 46.
    Brown LM, Swanson CA, Gridley G, et al (1995) Adenocarcinoma of the esophagus: role of obesity and diet. J Nat! Cancer Inst 87:1104–1109CrossRefGoogle Scholar
  47. 47.
    Chow W-H, Blot WJ, Vaughan TL, et al (1998) Body mass index and risk of adenocarcinoma of the esophagus and gastric cardia. J Nat! Cancer Inst 90:150–155PubMedCrossRefGoogle Scholar
  48. 48.
    Gray MR, Donnelly RJ, Kingsnorth IN, et al (1993) The role of smoking and alcohol in metaplasia and cancer risk in Barrett’s columnar lined esophagus. Gut 34:727–731PubMedCrossRefGoogle Scholar
  49. 49.
    Spechler SJ, Sperber H, Doos WG, et al (1983) The prevalence of Barrett’s esophagus in patients with chronic peptic esophageal strictures. Dig Dis Sci 28:769–774PubMedCrossRefGoogle Scholar
  50. 50.
    Weston AP, Badr AS, Topalovski M, et al (2000) Prospective evaluation of the prevalence of gastric Helicobacter pylori in patients with GERD, Barrett’s esophagus, Barrett’s dysplasia, and Barrett’s adenocarcinoma. Am J Gastroenterol 95:387–394PubMedCrossRefGoogle Scholar
  51. 51.
    Chow W-H, Finkle WD, McLaughlin JK, et al (1995) The relation of gastresophageal reflux disease and its treatment to adenocarcinomas of the esophagus and gastric cardia. JAMA 274:474–477PubMedCrossRefGoogle Scholar
  52. 52.
    Lagergren J, Bergstorm R, Lindgren A, et al (1999) Symptomatic gastresophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 340:825–831PubMedCrossRefGoogle Scholar
  53. 53.
    Patti MG, Goldberg HI, Arcerito M, et al (1996) Hiatal hernia size affects lower esophageal sphincter function, esophageal acid exposure, and degree of mucosal injury. Am J Surg 94:2054–2059Google Scholar
  54. 54.
    Menke-Pluymers MBE, Hop WCJ, Dees J, et al (1993) Risk factors for the development of an adenocarcinoma in Barrett’s esophagus. Cancer 72:1155–1158PubMedCrossRefGoogle Scholar
  55. 55.
    Jankowski J, Wright NA, Meltzer S, et al (1999) Molecular evolution of the metaplasia dysplasia sequence in the esophagus. Am J Pathol 154:969–974CrossRefGoogle Scholar
  56. 56.
    Jankowski J (1993) Gene expression in Barrett’s mucosa: modulation of acute and chronic responses. Gut 34:1012–1014CrossRefGoogle Scholar
  57. 57.
    Hamilton SR, Smith RR (1987) The relationship between columnar epithelial dysplasia and invasive adenocarcinoma arising in Barrett’s esophagus. Am J Clin Pathol 87:301–312PubMedGoogle Scholar
  58. 58.
    Reid BJ, Weinstein WM, Lewin KJ, et al (1988) Endoscopic biopsy can detect high-grade dysplasia or early adenocarcinoma in Barrett’s esophagus with or without grossly recognizable neoplastic lesions. Gastroenterology 94:81–90PubMedGoogle Scholar
  59. 59.
    Garewal HS, Sampliner RE, Fennerty MB, et al (1991) Flow cytometry in Barrett’s esophagus: what have we learned so for? Dig Dis Sci 36:548–551PubMedCrossRefGoogle Scholar
  60. 60.
    Boynton RF, Huang Y, Blount PL, et al (1991) Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancer. Cancer Res 51:5766–5769PubMedGoogle Scholar
  61. 61.
    Schneider PM, Casson AG, Levin B (1996) Mutation in p53 in Barrett’s esophagus and Barrett’s cancer: a prospective study of 98 cases. J Thorac Cardiovasc Surg 111:323–333PubMedCrossRefGoogle Scholar
  62. 62.
    Sjogren RW, Johnson LF (1983) Barrett’s esophagus: a review. Am J Med 74:313–321PubMedCrossRefGoogle Scholar
  63. 63.
    Bremner RM, DeMeester TR (1991) Surgical treatment of esophageal carcinoma. Gastroenterol Clin North Am 20:743–763PubMedGoogle Scholar
  64. 64.
    Starnes VA, Adkins RB, Ballinger JF, et al (1984) Barrett’s esophagus: a surgical entity. Arch Surg 119:563–567PubMedCrossRefGoogle Scholar
  65. 65.
    Bytzer P, Christensen PB, Damkier P, Vinding K, Seersholm N (1999) Adenocarcinoma of the esophagus and Barrett’s esophagus: a population-based study. Am J Gastroenterol 94: 86–91PubMedCrossRefGoogle Scholar
  66. 66.
    Sanfey H, Hamilton SR, Smith RRL (1985) Carcinoma arising in Barrett’s esophagus. Surg Gynecol Obstet 161:57–574Google Scholar
  67. 67.
    Akiyama H (1990) Surgery for cancer of the esophagus. Williams & Wilkins, Baltimore, p 10Google Scholar
  68. 68.
    Ojala K, Sorri M, Jokinin K (1982) Symptoms of carcinoma of the esophagus. Med J Aust 1:384–385PubMedGoogle Scholar
  69. 69.
    Cameron AJ, Zinmeiester AR, Ballard DJ, et al (1990) Prevalence of Columnar-lined (Barrett’s) esophagus. Gastroenterology 99:918–922PubMedGoogle Scholar
  70. 70.
    Bogomoletz WV, Molas G, Gayet B, et al (1989) Superficial squamous cell carcinoma of the esophagus: a report of 76 cases and review of the literature. Am J Surg Pathol 13:535–546PubMedCrossRefGoogle Scholar
  71. 71.
    Goseki N, Koike M, Yoshida M (1992) Histopathologic characteristics of early stage esophageal carcinoma: a comparative study with gastric carcinoma. Cancer 69:1088–1093PubMedCrossRefGoogle Scholar
  72. 72.
    Haruma K, Tokutomi T, Tsuda T, et al (1991) Superficial esophageal carcinoma: a report of 27 cases in Japan. Am J Gastroenterol 86:1723–1728PubMedGoogle Scholar
  73. 73.
    Zargar SA, Khuroo MS, Jan GM, et al (1991) Prospective comparison of the value of brushings before and after biopsy in the endoscopic diagnosis of gastroesophageal malignancy. Acta Cytol 35:549–552PubMedGoogle Scholar
  74. 74.
    Ohno S, Mori M, Tsutsui S, et al (1991) Growth patterns and prognosis of submucosal carcinoma of the esophagus: a pathologic study. Cancer 68:335–340PubMedCrossRefGoogle Scholar
  75. 75.
    Thompson JJ, Zinsser KR, Enterline HT, et al (1983) Barrett’s metaplasia and adenocarcinoma of the esophagus and gastroesophageal junction. Hum Pathol 14:43–61CrossRefGoogle Scholar
  76. 76.
    Richards FM, McKee SA, Rajpar MH, et al (1999) Germ-line E-cadherin gene (CDH1) mutations predispose to familial gastric and colorectal cancer. Hum Mol Genet 4:135–144Google Scholar
  77. 77.
    Canto MI, Setrakian S, Petras RE, et al (1996) Methylene blue selectively stains intestinal metaplasia in Barrett’s esophagus. Gastrointest Endosc 44:1–7PubMedCrossRefGoogle Scholar
  78. 78.
    Weston AP, Badr AS, Hassanein RS (1999) Prospective multivariate analysis of factors predictive of complete regression of Barrett’s esophagus. Am J Gastroenterol 94: 3420–3426PubMedCrossRefGoogle Scholar
  79. 79.
    Stevens PD, Lightdale CJ, Green HR, et al (1994) Combined endoscopy with chemoendoscopy for the evaluation of Barrett’s esophagus. Gastrointest Endosc 40:747PubMedCrossRefGoogle Scholar
  80. 80.
    Roth JA, Putnam JB, Rich TA, et al (1997) Cancer of the esophagus. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology, 5th edn. Lippincott-Raven, Philadelphia, pp 980–1021Google Scholar
  81. 81.
    Akiyama H, Tsurumaru M, Kawamura T, et al (1981) Principles of surgical treatment for carcinoma of esophagus; analysis of lymph node involvement. Ann Surg 194: 438–446PubMedCrossRefGoogle Scholar
  82. 82.
    Akiyama H, Tsurumaru M, Udagawa H, et al (1994) Radical dissection for cancer of the thoracic esophagus. Ann Surg 220:364–373PubMedCrossRefGoogle Scholar
  83. 83.
    Falk GW, Catalano MF, Sivak MV Jr, et al (1994) Endosonography in the evolution of patients with Barrett’s esophagus and high grade dysplasia. Gastrointest Endosc 40:207–212PubMedCrossRefGoogle Scholar
  84. 84.
    Ferguson MK, Naunheim KS (1997) Resection for Barrett’s mucosa with high-grade dysplasia and early adenocarcinoma: comparison of endoscopic biopsy and surgical pathology findings. J Thorac Cardiovasc Surg 114:824–829PubMedCrossRefGoogle Scholar
  85. 85.
    Overholt BF, Panjehpou M, Haydek JM (1999) Photodynamic therapy for Barrett’s esophagus: followup in 100 cases. Gastrointest Endosc 49:1–7PubMedCrossRefGoogle Scholar
  86. 86.
    Streitz JM, Andrews CW, Ellis FH Jr (1993) Endoscopic surveillance of Barrett’s esophagus: does it help? J Thorac Cardiovasc Surg 105:383–387PubMedGoogle Scholar
  87. 87.
    Levine DS, Haggit RC, Blount PL, et al (1993) An endoscopy biopsy protocol can differentiate high grade dysplasia from early adenocarcinoma in Barrett’s esophagus. Gastroenterology 105:40–50PubMedGoogle Scholar
  88. 88.
    Hagen JA, Peters JH, Demeester TR, et al (1993) Superiority of extended en bloc esophagogastrectomy for carcinoma of the lower esophagus and cardia. J Thorac Cardiovasc Surg 106:850–859PubMedGoogle Scholar

Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Sauid Ishaq
    • 1
  • Rebecca F. Harrison
    • 1
  • Janusz A. Jankowski
    • 1
  1. 1.Epithelial Laboratory, Division of Medical SciencesUniversity of BirminghamEdgbastonUK

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