Abstract
Mutation of TP53 is the most frequent genetic event in squamous cell carcinoma (SCC) and adenocarcinoma (ADC) of the esophagus. These mutations differ for SCC and ADC. In SCCs mutation patterns also differ from one geographic area to another. These mutations provide clues on the mutagenic mechanisms involved and confirm that SCC has multiple, region-specific causes.
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Tanière, P., Castren, K., Hainaut, P. (2002). Patterns of TP53 Mutations in Cancers of the Esophagus and Esophagogastric Junction: Correlation with Risk Factors and Functional Implications. In: Imamura, M. (eds) Superficial Esophageal Neoplasm. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67873-1_21
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DOI: https://doi.org/10.1007/978-4-431-67873-1_21
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