Oncogene Amplification and Oncoprotein Overexpression in Superficial Esophageal Cancer
The depth of tumor penetration is a crucial factor determining the prognosis of esophageal carcinoma patients [1,2]. Any carcinoma that extends no deeper than the submucosa is referred to as superficial esophageal carcinoma regardless of lymph node metastasis . Patients with superficial esophageal carcinomas, especially those limited to the mucosa, have significantly more favorable outcome than those with advanced cancer. On the other hand, the risk of nodal metastasis of submucosal carcinomas is about 35%, and the prognosis of these patients does not differ significantly from that of patients with advanced carcinoma. Whereas the frequency of superficial esophageal carcinomas in Western countries is still low , in Japan, because of intensified screening, the rate of superficial cancer has been increasing in recent years . Nevertheless, the features of superficial esophageal carcinoma, especially its molecular biologic aberrations, are poorly studied so far. In the current study we therefore investigated the frequency of oncogene amplification and oncoprotein overexpression in the two histological main types of esophageal cancer: squamous cell carcinoma (SCC) and adenocarcinoma (ADC). To determine if the molecular biology of superficial carcinoma differs significantly from that of advanced carcinoma, we compared our findings with a series of advanced esophageal SCCs and ADCs.
KeywordsEsophageal Cancer Esophageal Carcinoma Advanced Carcinoma EGFR Amplification Oncogene Amplification
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