Histopathologic Findings Predicting Lymph Node Metastasis and Prognosis of Patients with Superficial Esophageal Carcinoma

  • Yukihiro Nakanishi
Conference paper


Studies on patients with superficial squamous cell carcinoma of the esophagus (SSCCE) revealed that 0%–8.7% of mucosal carcinomas had lymph node metastases, whereas the incidence of lymph node metastasis in those with submucosal carcinomas was 43.6%–53.3% [1,2]. In recent years, endoscopic mucosal resection (EMR), a minimally invasive surgical procedure, has been performed with excellent results [3]. It has been proposed that EMR be indicated as a radical resection procedure for mucosal carcinomas [4]. EMR is associated with a low incidence of postoperative complications, and so far no patients have died as a result of this surgical technique [1]. Therefore, the indications for EMR may be able to be extended. To do so, it is important to establish the histopathologic findings that affect lymph node metastasis, so patients without lymph node metastasis can be excluded. However, as far as we are aware, there have been no studies involving a large number of patients with SSCCE in which the relation between the histopathologic findings and lymph node metastasis has been evaluated by multivariate analysis.


Histologic Grade Endoscopic Mucosal Resection Nuclear Atypia High Histologic Grade National Cancer Center Hospital 
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Copyright information

© Springer Japan 2002

Authors and Affiliations

  • Yukihiro Nakanishi
    • 1
  1. 1.Pathology DivisionNational Cancer Center Research InstituteTokyoJapan

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