Allograft of Composite Tissues: Experimental Model in the Rat

  • Akio Minami
  • Norimasa Iwasaki


Early experimental studies of vascularized joint and whole-limb allografts were performed using large animal models [1-6]. However, in some studies, a lack of defined major histo compatibility complex (MHC) barriers in these animals yielded variable allograft rejection and did not permit syngeneic controls. On the other hand, the rat is most suitable for studies of organ allogeneic transplantation, because a variety of inbred strains are available. In addition, with the development of microsurgical technique, the size of this animal is sufficient to permit a vascular anastomosis to be performed.


Ankle Joint Mycophenolic Acid Inguinal Ligament Femoral Vessel Major Histo Compatibility Complex 
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© Springer Japan 2003

Authors and Affiliations

  • Akio Minami
  • Norimasa Iwasaki

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