Vascularized Ulna Graft in the Rat

  • Nobuyuki Yamaoka
  • Susumu Tamai
  • Shigeru Mizumoto


When a vascularized fibula graft was performed for a bone defect in the extremity long bones, significant hypertrophy was observed when the graft was transferred to a mechanically loaded lower extremity, but less hypertrophy was observed when it was transfered to the upper extremities. This phenomenon of hypertrophy is related to the imposed mechanical stress load [1–3]. We designed a murine experiment to clarify the etiology of postoperative hypertrophy of vascularized bone grafts. We performed syngeneic vascularized ulna transfer to a segmental bone defect in the rat, with or without mechanical loading. The bone dynamics of the grafts were examined by fluarochrome bone labeling and histomorphological measurement.


Bone Formation Rate Xylenol Orange Vascularized Bone Graft Vascularized Fibula Graft Segmental Bone Defect 
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© Springer Japan 2003

Authors and Affiliations

  • Nobuyuki Yamaoka
  • Susumu Tamai
  • Shigeru Mizumoto

There are no affiliations available

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