OPLL pp 73-77 | Cite as

Metabolic Background of Ossification of the Posterior Longitudinal Ligament

  • Hiroshi Kawaguchi
  • Takahide Kurokawa
  • Yoshiaki Kodama
  • Toshio Matsumoto


Ossification of the posterior longitudinal ligaments (OPLL) was first reported in Japan [1], and has been shown to be a common disorder among the elderly population in East Asia [2]. Because of its prevalence in Asian countries, as well as its tendency to affect male patients and to occur within families, genetic susceptibility to the disease has been postulated and various genetic studies have been conducted (see Chapter Epidemiology by S. Matsunaga et al., this volume). In addition to the observations that suggest a genetic background of the disease, patients with OPLL show an increase in systemic bone mineral density [3], and a high incidence of OPLL has been reported in patients with metabolic and endocrinological disorders. These include derangements in mineral metabolism such as hypoparathyroidism and vitamin D-resistant hypophosphatemic rickets/osteomalacia, disturbances in glucose metabolism, and alterations in sex hormone and growth hormone secretion or action.


Serum Insulin Level Posterior Longitudinal Ligament Diffuse Idiopathic Skeletal Hyperostosis Spinal Ligament Compression Myelopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 1997

Authors and Affiliations

  • Hiroshi Kawaguchi
    • 1
  • Takahide Kurokawa
    • 1
  • Yoshiaki Kodama
    • 1
  • Toshio Matsumoto
    • 2
  1. 1.Department of Orthopaedic SurgeryUniversity of Tokyo School of MedicineBunkyo-ku, Tokyo, 113Japan
  2. 2.Fourth Department of Internal MedicineUniversity of Tokyo School of MedicineBunkyo-ku, Tokyo, 112Japan

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