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OPLL pp 59-64 | Cite as

Pathology of Spinal Cord Lesions Caused by Ossification of the Posterior Longitudinal Ligament

  • Yoshio Hashizume
  • Takashi Kameyama
  • Junichi Mizuno
  • Hiroshi Nakagawa
  • Tsutomu Yanagi
  • Mari Yoshida

Abstract

Ossification of the posterior longitudinal ligament (OPLL) causing spinal cord compression was first reported in 1838 by Key [1]; this was followed by only two reports [2,3] in the first part of this century. Ossification of the posterior longitudinal ligament was not recognized as a definite clinical entity until 1960. In Japan, Tsukimoto [4] first described this pathological condition following autopsy findings in 1960. Since then, a number of reports have appeared [5-8]. Increased recognition of OPLL led the Ministry of Public Health and Welfare of Japan to appoint a special study group, the Investigation Committee on OPLL, in 1974, and extensive studies ranging from basic research to clinical investigations have been conducted.

Keywords

Spinal Cord Anterior Horn Spinal Cord Lesion Posterior Longitudinal Ligament Cervical Myelopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Key CA (1838) On paraplegia, depending on disease of the ligaments of the spine. Guy’s Hosp Rep 3: 17–34Google Scholar
  2. 2.
    Knaggs RL (1925) Spondylitis deformans. Br J Surg 12: 524–546CrossRefGoogle Scholar
  3. 3.
    Oppenheimer A (1942) Calcification and ossification of vertebral ligaments (spondylitis ossificans ligamentosa): roentgen study of pathogenesis and clinical significance. Radiology 38: 160–173Google Scholar
  4. 4.
    Tsukimoto H (1960) A case report: autopsy of syndrome of compression of spinal cord owing to ossification within spinal canal of cervical spines (in Japanese). Nippon Geka Hokan (Kyoto) (Arch Jpn Chir) 29: 1003–1007Google Scholar
  5. 5.
    Koizumi M (1962) Three cases of spinal cord paralysis proved by ligamenta flava ossification (in Japanese). Rinsho Geka (Tokyo) (J Clin Surg) 17: 1181–1188Google Scholar
  6. 6.
    Suzuki K, Udagawa E, Nagano M, Takada S (1962) Ectopic calcification in the cervical epidural space and its clinical significance (in Japanese). Nippon Seikeigeka Gakkai Zasshi (J Jpn Orthop Assoc) 36: 256Google Scholar
  7. 7.
    Terayama K, Maruyama S, Miyashita R, Minai K, Kinoshita M, Shimizu Y (1964) On the ossification of ligament longitudinal posterior in the cervical spine (in Japanese). Seikeigeka (Tokyo) (Clin Orthop Surg) 15: 1083–1095Google Scholar
  8. 8.
    Onji Y, Akiyama H, Shimomura Y, Ono K, Hukuda S, Mizuno S (1967) Posterior paravertebral ossification causing cervical myelopathy: a report of eighteen cases. J Bone Jt Surg 49A: 1314–1328Google Scholar
  9. 9.
    Inoue K, Mannen T, Nakanishi T, Toyokura Y, Nagashima K (1976) An autopsy case of ossification of the posterior longitudinal ligament of the cervical spine (in Japanese). Shinkei Kenkyu No Shinpo (Tokyo) (Adv Neurol Sci) 20: 425–433Google Scholar
  10. 10.
    Ono K, Ota H, Tada K, Hamada H, Takaoka K (1977) Ossified posterior longitudinal ligament: a clinico-pathologic study. Spine 2: 126–138CrossRefGoogle Scholar
  11. 11.
    Murakami N, Muroga T, Sobue I (1978) Cervical myelopathy due to ossification of the posterior longitudinal ligament: a clinicopathological study. Arch Neurol 35: 33–36PubMedCrossRefGoogle Scholar
  12. 12.
    Hashizume Y (1980) Pathological studies on the ossification of the posterior longitudinal ligament. Acta Pathol Jpn 30: 255–273PubMedGoogle Scholar
  13. 13.
    Hashizume Y, Iijima S, Kishimoto H, Yanagi T (1984) Pathology of spinal cord lesions caused by ossification of the posterior longitudinal ligament. Acta Neuropathol (Berl) 63: 123–130CrossRefGoogle Scholar
  14. 14.
    Mizuno J, Nakagawa H, Iwata K, Hashizume Y (1992) Pathology of spinal cord lesions caused by ossification of the posterior longitudinal ligament, with special reference to reversibility of the spinal cord lesion. Neurol Res 14: 312–314PubMedGoogle Scholar
  15. 15.
    Yamaura I, Fujii K, Saito T, Isobe Y, Furuya K (1973) Ossification of the posterior longitudinal ligament in cervical spine, a necropsy case added (in Japanese). Kantouseisaishi (Kantov J Jpn Orthop Traomatol) 4: 268–273Google Scholar
  16. 16.
    Kameyama T, Hashizume Y, Ando T, Takahashi A, Yanagi T, Mizuno J (1995) Spinal cord morphology and pathology in ossification of the posterior longitudinal ligament. Brain 118: 263–278PubMedCrossRefGoogle Scholar
  17. 17.
    Mair WGP, Druckman R (1953) The pathology of spinal cord lesions and their relation to the clinical features in protrusions of cervical intervertebral discs. Brain 76: 7091Google Scholar
  18. 18.
    Yamzaki Y, Toda N, Nubotani T, Yamada K, Fukuda Y (1972) Anterior spinal artery syndrome by the ossification of the posterior longitudinal ligament in cervical spine, an autopsy case. Chubuseisaishi 15: 849–858Google Scholar
  19. 19.
    Braig A, Turnbull I, Hassler O (1966) Effects of mechanical stresses on the spinal cord in cervical spondylosis. Acta Radiol 4: 45–56Google Scholar
  20. 20.
    Kameyama T, Hahsizume Y, Sobue G (1996) Spinal cord cysts in compressive cervical myelopathy: a neuro-pathological study. In: Investigation committee report on the ossification of the cervical ligaments of the Japanese Ministry of Public Health and Welfare, Tokyo, June 1996Google Scholar
  21. 21.
    Mizuno J, Nakagawa H, Iwata K, Hashizume Y (1992) Compression myelopathy due to hypertrophy of the posterior longitudinal ligament associated with herniated intervertebral discs. Neuro-Orthopedics 13: 113–120Google Scholar
  22. 22.
    Kamiya M, Hahsizume Y (1989) Pathological studies of aberrant peripheral nerve bundles of spinal cords. Acta Neuropathol 79: 18–22PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1997

Authors and Affiliations

  • Yoshio Hashizume
    • 1
  • Takashi Kameyama
    • 2
  • Junichi Mizuno
    • 3
  • Hiroshi Nakagawa
    • 3
  • Tsutomu Yanagi
    • 4
  • Mari Yoshida
    • 1
  1. 1.Institute for Medical Science of AgingAichi Medical UniversityNagakute-cho, Aichi-gun, AichiJapan
  2. 2.Department of NeurologyNagoya University School of MedicineShowa-ku, Nagoya, AichiJapan
  3. 3.Departmemt of NeurosurgeryAichi Medical UniversityNagakute-cho, Aichi-gun, AichiJapan
  4. 4.Department of NeurologyNagoya Daini Red Cross HospitalShowa-ku, NagoyaJapan

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