OPLL pp 39-47 | Cite as

Pathological Findings of Ossification of the Posterior Longitudinal Ligament and Ossification of the Spinal Ligaments in an Experimental Animal Model

  • Yukio Miura
  • Ryo Hikone
  • Kengo Yamamoto
  • Kiyoshi Kawai
  • Satoshi Tanaka
  • Atsuhiro Imakiire


Patients with ossification of the posterior longitudinal ligament (OPLL) exhibit severe paralysis of the spinal cord, and such cases are classified as a recalcitrant disease by the Japanese Ministry of Health and Welfare. However, the etiology of this condition has not yet been clarified. The first report in Japan was made by Tsukimoto [1] in 1960, and in 1975 the Japanese Ministry of Health and Welfare research group was formed. Initially, investigations centered on cases of OPLL, but when it was discovered that ossification develops in various spinal ligaments, the concept of ossification of the spinal ligaments (OSL) became established.


Posterior Longitudinal Ligament Anterior Longitudinal Ligament Spinal Ligament Yellow Ligament Active Chondrocytes 
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Copyright information

© Springer Japan 1997

Authors and Affiliations

  • Yukio Miura
    • 1
  • Ryo Hikone
    • 1
  • Kengo Yamamoto
    • 1
  • Kiyoshi Kawai
    • 1
  • Satoshi Tanaka
    • 1
  • Atsuhiro Imakiire
    • 1
  1. 1.Department of Orthopedic SurgeryTokyo Medical CollegeTokyo, 160Japan

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